Teaching Designing for Additive Manufacturing: Formulating Educational Interventions That Encourage Design Creativity.

As additive manufacturing (AM) processes become more ubiquitous in engineering, design, and manufacturing, the need for a workforce skilled in designing for additive manufacturing (DfAM) has grown. Despite this need for an AM-skilled workforce, little research has systematically investigated the formulation of educational interventions for training engineers in DfAM. In this article, we synthesize findings from our experiments with 596 engineering design students to inform the development of educational interventions-comprising content presentations and design tasks-that encourage student learning and creativity.

Publisher Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

In the version of this article initially published, the label over the bottom schematic in Fig. 1a was "pH > 5.0"; it should have been "pH < 5.

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers.

Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS. Downstream of KRAS, the RAF→MEK→ERK signaling pathway plays a central role in pancreatic carcinogenesis. However, paradoxically, inhibition of this pathway has provided no clinical benefit to patients with PDA.