Publications by authors named "Stephanie L Barta"
Mol Nutr Food Res
April 2008
Article Synopsis
- The study examined how beta-sitosterol (SIT) and the antiestrogen drug tamoxifen (TAM) affect cell growth and ceramide (CER) metabolism in two types of human breast cancer cells: MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative).
- Both SIT and TAM inhibited cell growth, with SIT having a stronger effect across both cell lines, while TAM specifically inhibited MCF-7 growth.
- The combination of SIT and TAM significantly increased CER levels, which promote cell death, with SIT enhancing CER synthesis and TAM preventing CER modification, indicating potential benefits for breast cancer treatment with this combination.
