Publications by authors named "Stephanie K Jeong"
Proc Natl Acad Sci U S A
October 2017
Article Synopsis
- The enzyme serine hydroxymethyltransferase (SHMT) converts serine into glycine and plays a crucial role in synthesizing essential molecules for cell growth, with two isoforms (SHMT1 and SHMT2) identified in mammals.
- A study found that knocking out both SHMT1 and SHMT2 in colon cancer cells effectively prevents tumor formation, and they developed small-molecule inhibitors that target both versions of the enzyme.
- In particular, diffuse large B-cell lymphoma (DLBCL) was shown to be sensitive to SHMT inhibition, as these cancer cells struggle with glycine uptake, making them reliant on SHMT activity to satisfy their glycine requirements.
