Publications by authors named "Stephanie Jacquez"
Article Synopsis
- Targeted gene delivery and toxicity issues are major challenges in gene therapy, but this study presents a new approach using dimerized HIV-1 TAT peptide in a nanoparticle vector for more effective tumor targeting.
- The dTAT NP demonstrated high transfection efficiency with low cytotoxicity in both cell culture experiments and in live tumor models, showing long-lasting gene expression in tumor tissues.
- Additionally, the dTAT NP effectively reduced tumor growth when delivering specific plasmid DNA, supporting its potential as a promising method for lung cancer gene therapy through intratracheal administration.
