Publications by authors named "Stephanie J Grimaldi"
High-dose ondansetron reduces activation of interoceptive and sensorimotor brain regions.
Neuropsychopharmacology
January 2019
Several psychiatric disorders involve abnormalities of interoception and associated neural circuitry centered on the insula. The development of interventions modulating interoceptive circuits could lead to novel treatment approaches for these disorders. The 5-HT3 receptor antagonist ondansetron is a good candidate for the modulation of interoceptive circuits, as 5-HT3 receptors are located abundantly on sensory pathways and ondansetron has shown some clinical utility in disorders characterized by sensory and interoceptive abnormalities.
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- Interoception is the awareness of internal body sensations, which includes how individuals interpret and use these sensations for behavior.
- Research on healthy individuals found that when focusing on heartbeat and skin temperature, specific brain regions like the insula and sensorimotor areas were activated.
- The study identified three components of interoceptive sensibility (IS), with one being linked to brain activity, highlighting that difficulties in attending to body sensations may correlate with increased brain activation in areas responsible for monitoring bodily states.