Markers for DNA damage are induced in the rat colon by the toxin altertoxin-II, but not a complex extract of cultured .

Mycotoxins produced by spp. act genotoxic in cell-based studies, but data on their toxicity is scarce and urgently required for risk assessment. Thus, male Sprague-Dawley rats received single doses of a complex toxin extract (CE; 50 mg/kg bw), altertoxin II (ATX-II; 0.

Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships.

Scope: Glycosylation is a way to increase structure-stability of anthocyanins, yet compromises their bioactivity. The study investigates the antioxidant activity of purified cyanidin (Cy)-based anthocyanins and respective degradation products in Caco-2 clone C2BBe1 aiming to identify structure-activity relationships.

Results And Methods: Cyanidin 3-O-glucoside (Cy-3-glc) and cyanidin 3-O-sambubioside (Cy-3-sam) proved to be most potent regarding antioxidant properties and protection against hydrogen peroxide (H O )-induced reactive oxygen species (ROS)-levels measured with the dichloro-fluorescein (DCF) assay.

Bioavailability, metabolism, and excretion of a complex Alternaria culture extract versus altertoxin II: a comparative study in rats.

Despite the frequent infection of agricultural crops by Alternaria spp., their toxic secondary metabolites and potential food contaminants lack comprehensive metabolic characterization. In this study, we investigated their bioavailability, metabolism, and excretion in vivo.

Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus.

Intracellular delivery of bioactive polyphenols is currently evaluated as a protective strategy for cells under pharmaceutical stress. To this end, the 20mer R5 peptide from the marine diatom C. fusiformis was N-terminally modified with a quercetin derivative.

Pulsed Sagnac source of polarization entangled photon pairs.

Photonic quantum information experiments demand bright and highly entangled photon pair sources. The combination of periodic poling and collinear excitation geometry allows the use of considerably longer crystals for parametric down-conversion. We demonstrate a picosecond-pulsed laser pumped source of high quality polarization entangled photon pairs.