High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.

Tick bites, associated with the secretion of tick saliva containing the xenoglycan galactose-alpha-1, 3-galactose (alpha-gal or aGal), are recognized as the causal factors of alpha-Gal syndrome (AGS; or red meat allergy) in humans. AGS occurs after the increased production of IgE antibodies against aGal, which is found in most mammalian cells, except for the Old World monkey and humans. The aGal sensitization event has been linked to an initial tick bite, followed by consumption of red meat containing the aGal glycan, which triggers the onset of the allergic response resulting in urticaria, anaphylaxis, or even death.

Multiple physiological cohorts comprise seasonal activity of wild Amblyomma americanum (Acari: Ixodidae) nymphs.

Nymphs of the hard tick Amblyomma americanum (L.) are an important life stage in the maintenance and transmission of tick-borne pathogens. As pathogen composition can vary across developmental cohorts, it is essential to understand the demographic structure of the questing population.

Seasonal changes in questing efficiency of wild Amblyomma americanum (Acari: Ixodidae) nymphs.

Understanding the factors which influence host-seeking behavior of ticks is essential to determine the risk they pose as a vector of pathogens. While many studies have evaluated the impact of environmental variables on tick behavior, few have examined how seasonal changes in physiological status may further modify patterns of activity. In this study, we measured differences in questing behavior of mid spring- and early summer-caught Amblyomma americanum nymphs held under standardized laboratory conditions.

Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis.

The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive experiences. We showed that developing habenular circuits exhibit multiple alterations that lead to an increase in the structural and functional diversity of cell types, inputs, and functional modules.

Habenula: A Role in Brain State Transitions during Coping Behavior.

What is the link between behavioral states and neural dynamics in the brain? New research using zebrafish has revealed a unique activity pattern in the brain, sequentially recruiting multiple habenular neurons, during the transition from active to passive coping behavior.

Ecological modeling over seven years to describe the number of host-seeking Amblyomma americanum in each life stage in northeast Missouri.

Amblyomma americanum (L.), the lone star tick, is a vector of pathogens in humans and other animals throughout the United States. Our objective was to characterize how environmental factors influence patterns of A.

Information processing in the vertebrate habenula.

The habenula is a brain region that has gained increasing popularity over the recent years due to its role in processing value-related and experience-dependent information with a strong link to depression, addiction, sleep and social interactions. This small diencephalic nucleus is proposed to act as a multimodal hub or a switchboard, where inputs from different brain regions converge. These diverse inputs to the habenula carry information about the sensory world and the animal's internal state, such as reward expectation or mood.

Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations.

Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical properties of cilia. Here we show that the motile cilia in the nose of aquatic vertebrates are spatially organized and stably beat with an asymmetric pattern, resulting in a robust and stereotypical flow around the nose.

Chemical attraction of Dermacentor variabilis ticks parasitic to Peromyscus leucopus based on host body mass and sex.

Macroparasites are commonly aggregated on a small subset of a host population. Previous explanations for this aggregation relate to differences in immunocompetence or the degree to which hosts encounter parasites. We propose active tick host choice through chemical attraction as a potential mechanism leading to aggregated tick burdens.

Modeling the influence of Peromyscus leucopus body mass, sex, and habitat on immature Dermacentor variabilis burden.

Immature (larvae and nymph) tick burden on rodents is an important determinant of adult tick population size and understanding infectious disease dynamics. The objective of this research was to build a descriptive model for immature Dermacentor variabilis burden on Peromyscus leucopus. Mice were live-trapped on two permanent grids in an old field and an early successional forest every other month between April and October, 2006-2009.

A quantitative comparison of two sample methods for collecting Amblyomma americanum and Dermacentor variabilis (Acari: Ixodidae) in Missouri.

In studies of tick communities, sampling methodology may influence observed patterns. The objective of this study was to compare two sampling methods, dragging and dry ice baiting, in two habitats to assess abundance of off-host ticks. Tick communities were monitored from March to December in a forested and an old-field habitat in northeast Missouri.