The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes).

Background: The human apolipoprotein E (APOE) gene is polymorphic, with three primary alleles (E2, E3, E4) that differ at two key non-synonymous sites. These alleles are functionally different in how they bind to lipoproteins, and this genetic variation is associated with phenotypic variation for several medical traits, including cholesterol levels, cardiovascular health, Alzheimer's disease risk, and longevity. The relative frequencies of these alleles vary across human populations, and the evolution and maintenance of this diversity is much debated.

Leptin associations with age, weight, and sex among chimpanzees (Pan troglodytes).

Background: Leptin is a hormone secreted primarily by adipocytes, a lipostatic signal to the hypothalamus, and is often correlated with adiposity. Associations between leptin, age, and development are unknown in human's closest evolutionary relative, the common chimpanzee (Pan troglodytes).

Methods: Serum leptin was assessed cross sectionally in association with age, weight, and sex in healthy captive chimpanzee males (n = 47) and females (n = 49) to test hypotheses related to predicted differences in leptin levels with body mass, development, and sexual dimorphism.

Specific gravity as an alternative to creatinine for estimating urine concentration in captive and wild chimpanzee (Pan troglodytes) Samples.

The measurement of hormones in urine has become a widely used technique in primatology. Because urine concentration varies according to fluid intake, concentration must be measured in each sample collected, and hormone values are always expressed per unit of concentration. Traditionally, creatinine has been used as a concentration index, but some studies in humans have shown that creatinine varies among populations and even within and between individuals within a population, and that it begins to degrade after just one freeze-thaw cycle.

Age, rank, and personality effects on the cortisol sedation stress response in young chimpanzees.

Primates and other mammals exhibit a glucocorticoid response to somatic and psychosocial stressors. The pattern and degree of response varies both within and between species, but the factors affecting within-species variability have rarely been considered. Here we describe the 90-min serum cortisol response of 14 juvenile and adolescent chimpanzees to the stress of sedation with ketamine hydrochloride.

Testosterone in juvenile and adolescent male chimpanzees (Pan troglodytes): effects of dominance rank, aggression, and behavioral style.

Testosterone is a steroid hormone with diverse effects on male reproductive function and behavior. The relationship between testosterone and social behavior such as mating and aggression has been investigated in a variety of primate species, but few such studies have been conducted on chimpanzees, and even fewer on primates during the juvenile and adolescent periods. This study explores the relationship between baseline urinary testosterone and behavioral variables including dominance rank, rates of aggression toward peers, and behavioral style in 16 juvenile and adolescent male chimpanzees (Pan troglodytes) living at the New Iberia Research Center in Louisiana.

Rapid changes in chimpanzee (Pan troglodytes) urinary cortisol excretion.

Behavioral endocrinologists are aware that many hormones exhibit a diurnal rhythm, and attempt to correct for this pattern by collecting physiological samples only during specified time windows of varying lengths. In studies utilizing urinary measures of hormone levels, this window often spans 2 h or longer. In this study, we compared chimpanzee urinary cortisol levels in sample pairs collected within 1 h of each other in an attempt to validate the use of a time window for sample collection.