The influence of hydrogen ions on coagulation in traumatic brain injury, explored by molecular dynamics.

: Patients in intensive care units with traumatic brain injuries (TBI) frequently present acid-base abnormalities and coagulability disorders, which complicate their condition.: To identify protonation through simulations of molecules involved in the process of coagulation in standard laboratory tests.: Ten patients with TBI were selected from the intensive care unit in addition to ten "healthy control subjects", and another nine patients as "disease control subjects"; the latter being a comparative group, corresponding to subjects with diabetes mellitus 2 (DM2).