Publications by authors named "Stephanie Devoe"
Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vβ2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand.
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- The study investigates how neutrophil extracellular traps (NETs) in the lung might lead to the production of anti-citrullinated protein antibodies (ACPAs) in individuals at risk of rheumatoid arthritis (RA).
- Researchers analyzed sputum from 49 at-risk subjects, 12 RA patients, and 18 controls, measuring NET formation and ACPA levels.
- Results show that higher levels of Cit-H3-expressing NETs correlate with increased ACPA in at-risk individuals, suggesting inflammation in the lungs may drive local ACPA generation, which could contribute to the onset of RA.