Publications by authors named "Stephanie Cristine Hepp Rehfeldt"
Article Synopsis
- Luteolin-7-O-glucoside (Lut7) shows potential benefits for the central nervous system by reducing inflammation, oxidative stress, and neuronal damage.
- In lab tests, Lut7 improved cell viability in both undifferentiated and differentiated SH-SY5Y cells exposed to neurotoxic conditions and demonstrated high antioxidant activity compared to synthetic alternatives.
- Lut7 treatment also modulated inflammatory cytokines in immune cells, suggesting its neuroprotective effects may warrant further investigation for treating neurodegenerative diseases.
Article Synopsis
- Current treatments for neurodegenerative diseases mainly relieve symptoms but do not slow disease progression, highlighting the need for effective therapies.
- The study investigates the compound FMU200, which inhibits JNK3, for its neuroprotective, anti-inflammatory, and antioxidant properties using cell lines SH-SY5Y and RAW264.7.
- Results indicate that FMU200 significantly reduces cell damage from neurotoxins, decreases apoptosis, lowers reactive oxygen species, restores mitochondrial function, and diminishes inflammatory responses, suggesting its potential as a treatment option for neurodegenerative disorders.
Alzheimer's Disease (AD) is becoming more prevalent as the population lives longer. For individuals over 60 years of age, the prevalence of AD is estimated at 40.19% across the world.
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