Publications by authors named "Stephanie C Frank"
TRPM8 is a Ca-permeable nonselective cation channel belonging to the melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly overexpressed in a variety of tumor entities including glioblastoma multiforme where it reportedly contributes to tumor invasion. The present study aimed to disclose further functions of TRPM8 in glioma biology in particular upon cell injury by ionizing radiation.
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- The study investigates haptotaxis, the process where cells migrate towards gradients of proteins attached to a substrate, highlighting the mechanics behind it that are not well understood.
- Researchers created controlled fibronectin dot patterns to analyze how various factors like dot size and concentration affect fibroblast movement, finding that specific conditions led to optimal cell migration towards areas of higher fibronectin density.
- The findings revealed that cell movement depends on intracellular forces and interactions among proteins like RhoA, Cdc42, and aPKCζ, which play crucial roles in recognizing and responding to adhesive gradients during haptotaxis.
In vivo, cells are exposed to mechanical forces in many different ways. These forces can strongly influence cell functions or may even lead to diseases. Through their sensing machinery, cells are able to perceive the physical information of the extracellular matrix and translate it into biochemical signals resulting in cellular responses.
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