Automatic Cocrystal Detection by Raman Spectral Deconvolution-Based Novelty Analysis.

Cocrystals are important molecular adducts that have many advantages as a means of modifying the physicochemical properties of active pharmaceutical ingredients, including taste masking and improved solubility, bioavailability, and stability. As a result, the discovery of new cocrystals is of great interest to commercial drug discovery programs. Time-consuming manual analysis of the large volumes of data that emerge from large-scale cocrystal screening programs of up to 1000s of preparations poses a challenge.

Development and in vitro testing of a new method of urine preparation for retrograde ejaculation; the Liverpool solution.

Objective: To design a new method for oral preparation of urine for sperm retrieval after retrograde ejaculation (RE) and to test the motility of sperm exposed to prepared and unprepared urine.

Design: In vitro testing of urine conditions and sperm motility.

Setting: Assisted conception unit at a teaching hospital in the United Kingdom.