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Publications by authors named "Stephanie Albouhair"

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Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.
Stéphanie Albouhair Ester Morgado Catherine Lavau

PLoS One

January 2015

Leukemias harboring MLL translocations are frequent in children and adults, and respond poorly to therapies. The receptor tyrosine kinase FLT3 is highly expressed in these leukemias. In vitro studies have shown that pediatric MLL-rearranged ALL cells are sensitive to FLT3 inhibitors and clinical trials are ongoing to measure their therapeutic efficacy.

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Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation.
Ester Morgado Stéphanie Albouhair Catherine Lavau

Blood

May 2007

HOX genes, MEIS1, and FLT3 are frequently up-regulated in human myeloid leukemias. Meis1 cooperates with Hox genes to induce leukemias in mice, hypothetically the consequence of Meis1-induced Flt3 overexpression. To test this, we compared the properties of Flt3(-/-) and Flt3(+/+) progenitors transduced with Hoxa9 or Hoxa9/Meis1.

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Synopsis of recent research by authors named "Stephanie Albouhair"

  • - Stephanie Albouhair's research focuses on the role of the FLT3 receptor tyrosine kinase in various forms of myeloid leukemia, particularly in the context of MLL fusion genes and HOX gene interactions.
  • - Findings indicate that FLT3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes, challenging previously held assumptions about its significance and therapeutic targeting in such leukemias.
  • - Additionally, her studies reveal that FLT3 is dispensable for the leukemogenic cooperation between Hoxa9 and Meis1, suggesting alternative mechanisms driving the pathology of human myeloid leukemias, thus altering the therapeutic approach to these malignancies.

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