Publications by authors named "Stephanie A Osganian"
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver condition, and the study aimed to differentiate between simpler steatosis and the more severe nonalcoholic steatohepatitis (NASH) using CT texture analysis.
- Sixteen NAFLD patients underwent liver biopsies and CT scans to analyze gray-level texture features, finding that those with NASH had distinct CT texture results compared to those with simple steatosis.
- The results indicated that lower entropy and mean pixel values could reliably predict NASH, suggesting that CT texture analysis could be an innovative tool for assessing liver disease progression.
Objective: The GH and IGF-1 axis is a candidate disease-modifying target in nonalcoholic fatty liver disease (NAFLD) given its lipolytic, anti-inflammatory and anti-fibrotic properties. IGF-1 receptor (IGF-1R) and GH receptor (GHR) expression in adult, human hepatic tissue is not well understood across the spectrum of NAFLD severity. Therefore, we sought to investigate hepatic IGF-1R and GHR expression in subjects with NAFLD utilizing gene expression analysis (GEA) and immunohistochemistry (IHC).
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- * Studies using various gene-targeting methods showed that silencing TAZ in liver cells of NASH-afflicted mice reduces HCC tumor growth by impacting oxidative DNA damage pathways.
- * The findings suggest that targeting TAZ and its associated oxidative stress mechanisms could offer new therapeutic strategies for managing NASH and preventing HCC development.
Background & Aims: Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is essential to predict liver-related outcomes and guide treatment decisions. A protein-based signature of fibrosis could serve as a valuable, non-invasive diagnostic tool. This study sought to identify circulating proteins associated with fibrosis in NAFLD.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is independently associated with obesity and cardiovascular disease (CVD). CVD is the primary cause of mortality in the predominantly obese population of adults with NAFLD. NAFLD is increasingly seen in individuals who are lean and overweight (i.
View Article and Find Full Text PDFApproaches to manage nonalcoholic fatty liver disease (NAFLD) are limited by an incomplete understanding of disease pathogenesis. The aim of this study was to identify hepatic gene-expression patterns associated with different patterns of liver injury in a high-risk cohort of adults with obesity. Using the NanoString Technologies (Seattle, WA) nCounter assay, we quantified expression of 795 genes, hypothesized to be involved in hepatic fibrosis, inflammation, and steatosis, in liver tissue from 318 adults with obesity.
View Article and Find Full Text PDFBackground: Nonalcoholic fatty liver disease (NAFLD) and HIV are independently associated with cardiovascular disease (CVD). However, the factors associated with NAFLD in persons living with HIV (PWH) and whether CVD is more frequent in PWH with NAFLD are currently unknown.
Methods: From the Partners HealthCare Research Patient Data Registry, we identified PWH with and without NAFLD between 2010 and 2017.
Objectives: The mechanisms responsible for the development of nonalcoholic fatty liver disease (NAFLD) and progression to nonalcoholic steatohepatitis (NASH) are incompletely understood. Growing evidence suggests that growth hormone (GH) and insulin-like growth factor-1 (IGF-1) may have roles in the development and progression of NAFLD. We hypothesized that lower serum IGF-1 levels would be associated with increased liver fat accumulation, inflammation, and fibrosis in a group of meticulously phenotyped obese subjects with liver biopsies.
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