Publications by authors named "Stephanie A Hart"
DEK::AFF2 fusion nonkeratinizing squamous cell carcinoma (NKSCC) is an emerging entity in the sinonasal tract, temporal bone, and skull base. However, the clinical behavior of these tumors has not been well studied. Here, we report the largest cohort of DEK::AFF2 carcinomas to determine if morphology, mitotic rate, and/or Ki-67 IHC are associated with patient outcomes, including a comparison with high-risk human papillomavirus (HPV)-associated and independent patients.
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- The study compared the International Consensus (ICC) and World Health Organization (WHO5) classifications for myeloid diseases involving TP53 mutations, reviewing 188 cases.
- A significant 64% of cases were classified differently between the two systems, particularly due to ICC's inclusion of complex karyotype (CK) as a marker for biallelic TP53 inactivation.
- The findings show that TP53-mutated acute myeloid leukemia (AML) has distinct characteristics and worse survival compared to non-mutated cases, suggesting the need for better classification in future systems to recognize these differences.
Objectives: The goal of this study was to assess hospital compliance with federal price transparency mandates and barriers to pricing information in Tennessee.
Methods: All hospitals websites were queried for gross, cash, and BlueCross BlueShield of Tennessee prices for 8 high-frequency laboratory tests in 2 Centers for Medicare & Medicaid Services-mandated pricing sources: (1) a machine-readable file of all available services and (2) a consumer-friendly display of 300 shoppable services. Barriers, including click counts, data availability, and intrahospital price discrepancies, were noted.
Post-traumatic stress disorder (PTSD) is a debilitating condition that only occurs in the aftermath of traumatic event exposure and is characterized by an impaired stress response and chronic, low-grade inflammation. Dysregulation of the immune system may contribute towards central nervous system tissue damage and exacerbation of fear memories following trauma. Patients with PTSD often have comorbid psychiatric and somatic disorders that are of themselves associated with heightened inflammation.
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