Effect of IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children.

Background And Objectives: HIV enteropathy may cause disruption of the intestinal barrier, leading to a loss of CD4+ T cells, increased intestinal permeability, and microbial translocation. IS-10506 has the ability to improve gut barrier function. This study investigated the effect of IS-10506 on a number of biomarkers of enteropathy-related damage in HIV-infected paediatric patients undergoing antiretroviral therapy (ARV).