Publications by authors named "Stephane Nicolle"

The aim of the current study is to demonstrate the feasibility of radiofrequency (RF) pulses generated via an optimal control (OC) algorithm to perform magnetic resonance elastography (MRE) and quantify the mechanical properties of materials with very short transverse relaxation times (T2 < 5 ms) for the first time. OC theory applied to MRE provides RF pulses that bring isochromats from the equilibrium state to a fixed target state, which corresponds to the phase pattern of a conventional MRE acquisition. Such RF pulses applied with a constant gradient allow to simultaneously perform slice selection and motion encoding in the slice direction.

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Introduction: Elastic skin fibers lose their mechanical properties during aging due to enzymatic degradation, lack of maturation, or posttranslational modifications. Dill extract has been observed to increase elastin protein expression and maturation in a 3D skin model, to improve mechanical properties of the skin, to increase elastin protein expression in vascular smooth muscle cells, to preserve aortic elastic lamella, and to prevent glycation.

Objective: The aim of the study was to highlight dill actions on elastin fibers during aging thanks to elastase digestion model and the underlying mechanism.

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Article Synopsis
  • The study focuses on the importance of characterizing brain tissue to improve understanding of neurological disorders, using mechanical characterization as a new approach.
  • The researchers aimed to validate a transient ultrasound technique by comparing it with established methods like a rotating plate rheometer and viscoelastic spectroscopy, finding it reliable for measuring storage modulus dispersion.
  • Finally, they applied this validated technique to ex vivo human white matter, successfully measuring the mechanical characteristics and fitting the data with a custom power law model.
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This research aims at improving the definition of the shear linear material properties of brain tissue. A comparison between human and porcine white and gray matter samples was carried out over a new large frequency range associated with both traffic road and non-penetrating ballistic impacts. Oscillatory experiments were performed by using an original custom-designed oscillatory shear testing device.

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