Publications by authors named "Stephane Goumard"
Oncogenic ras activates multiple signaling pathways to enforce cell proliferation in tumor cells. The ERK1/2 mitogen-activated protein kinase pathway is required for the transforming effects of ras, and its activation is often sufficient to convey mitogenic stimulation. However, in some settings oncogenic ras triggers a permanent cell cycle arrest with features of cellular senescence.
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- - Cellular senescence is a permanent cessation of cell division triggered by stresses like short telomeres or activated oncogenes, with Promyelocytic leukemia protein (PML) playing a key role in initiating this process in human diploid fibroblasts (HDFs).
- - PML-induced senescence involves increased p53 activity, accumulation of hypophosphorylated Rb, and decreased E2F-dependent gene expression, but the presence of HPV oncoproteins E6 and E7 can inhibit this growth arrest.
- - Specifically, E7 can completely block PML-induced senescence by targeting the Rb pathway, while E6 can only delay it, indicating that the Rb tumor-suppressor