Publications by authors named "Stephane Champagne"

Background Ischemic late gadolinium enhancement (LGE) assessed with cardiac MRI is a well-established prognosticator in ischemic cardiomyopathy. However, the prognostic value of additional LGE parameters, such as extent, transmurality, location, and associated midwall LGE, remains unclear. Purpose To assess the prognostic value of ischemic LGE features to predict all-cause mortality in ischemic cardiomyopathy.

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Aortic valve-in-valve (ViV) procedures are increasingly performed for the treatment of surgical bioprosthetic valve failure in patients at intermediate to high surgical risk. Although ViV procedures offer indisputable benefits in terms of procedural time, in-hospital length of stay, and avoidance of surgical complications, they also present unique challenges. Growing awareness of the technical difficulties and potential threats associated with ViV procedures mandates careful preprocedural planning.

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Article Synopsis
  • This study examined whether an AI-based method for measuring left ventricular ejection fraction (LVEF) during stress tests could better predict death in patients compared to traditional methods.
  • Researchers analyzed data from over 9,700 patients, finding a strong correlation between AI-measured stress LVEF and expert-measured LVEF, as well as a significant association with all-cause mortality.
  • The study concluded that the AI method provides valuable prognostic information that improves risk assessment beyond conventional factors and traditional stress CMR findings.
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  • Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, yet the prognostic value of stress cardiovascular magnetic resonance (CMR) in these patients isn't fully established.
  • * A study analyzed 825 symptomatic CKD patients, focusing on the safety and predictive value of vasodilator stress CMR, while excluding patients with severe kidney impairment due to risks associated with gadolinium.
  • *Results showed that stress CMR was well tolerated and the presence of inducible ischemia significantly increased the risk of major adverse cardiovascular events, highlighting stress CMR as a critical tool for predicting outcomes in CKD patients.
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Introduction And Objectives: Coronary chronic total occlusions (CTO) involving bifurcation lesions are a challenging lesion subset that is understudied in the literature. This study analyzed the incidence, procedural strategy, in-hospital outcomes and complications of percutaneous coronary interventions (PCI) for bifurcation-CTO (BIF-CTO).

Methods: We assessed data from 607 consecutive CTO patients treated at the Institut Cardiovasculaire Paris Sud (ICPS), Massy, France between January 2015 and February 2020.

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  • The study aimed to evaluate if fully automated AI-based global circumferential strain (GCS) measured during stress cardiovascular MRI can provide additional predictive value for major adverse cardiovascular events (MACE).
  • The research involved over 2,100 patients and found that while stress-GCS correlated with MACE in patients with normal stress CMR, it did not predict such events in those with abnormal CMR.
  • The findings suggest that stress-GCS offers better prognostic assessment in individuals with normal CMR compared to traditional methods, despite a low overall event rate among these patients.
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Background: The left atrioventricular coupling index (LACI) is a strong and independent predictor of heart failure (HF) in individuals without clinical cardiovascular disease. Its prognostic value is not established in patients with cardiovascular disease.

Objectives: This study sought to determine in patients undergoing stress cardiac magnetic resonance (CMR) whether fully automated artificial intelligence-based LACI can provide incremental prognostic value to predict HF.

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Background: Inconclusive non-invasive stress testing is associated with impaired outcome. This population is very heterogeneous, and its characteristics are not well depicted by conventional methods.

Aims: To identify patient subgroups by phenotypic unsupervised clustering, integrating clinical and cardiovascular magnetic resonance data to unveil pathophysiological differences between subgroups of patients with inconclusive stress tests.

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Background: One-third of ischemic strokes are "cryptogenic" without clearly identified etiology. Although coronary artery disease (CAD) is the main cause of death after stroke, the interest in CAD screening in patients with cryptogenic stroke is still debated.

Aim: The aim of the study was to assess the incremental prognostic value of stress cardiovascular magnetic resonance (CMR) beyond traditional risk factors for predicting cardiovascular events in patients with a prior cryptogenic ischemic stroke.

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Article Synopsis
  • - This study evaluates the prognostic value of stress cardiac magnetic resonance (CMR) imaging for patients with obstructive coronary artery disease (CAD) whose condition is not clearly defined through coronary computed tomography angiography (CTA).
  • - Over a median follow-up of 6.8 years, about 13.8% of the patients experienced major cardiovascular events (MACEs), with factors like inducible ischemia and late gadolinium enhancement showing significant correlations with these events.
  • - The research concluded that stress CMR offers better predictive capabilities for adverse cardiovascular outcomes compared to traditional risk assessments and coronary CTA, highlighting its importance in clinical decision-making for symptomatic patients.
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Background: In patients with suspected or known coronary artery disease, traditional prognostic risk assessment is based on a limited selection of clinical and imaging findings. Machine learning (ML) methods can take into account a greater number and complexity of variables.

Objectives: This study sought to investigate the feasibility and accuracy of ML using stress cardiac magnetic resonance (CMR) and clinical data to predict 10-year all-cause mortality in patients with suspected or known coronary artery disease, and compared its performance with existing clinical or CMR scores.

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Background: X-ray exposure during complex percutaneous coronary intervention is a very important issue.

Aim: To reduce patient peak skin dose during percutaneous coronary intervention procedures for chronic total occlusion using on-line estimated peak skin dose software (Dose Map).

Methods: Throughout the procedure, Dose Map provided a map of local cumulative peak skin dose.

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Introduction: Long drug-eluting stents may limit the issue of overlapping multiple stents when treating long coronary lesions.

Aim: The aim of the study was to assess the safety and efficacy of the 48 mm Xience Xpedition everolimus-eluting stent (48mm-EES) for the treatment of long coronary lesions, in an all-comer population.

Methods: Patients receiving at least one 48mm-EES were prospectively included from March 2014 to December 2018.

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Objectives: The aim of this study was to identify independent angiographic predictors of collateral channel (CC) tracking success, microcatheter tracking failure, and complications in chronic total occlusion (CTO) retrograde approach. We also developed a "crossability score," comparing its predictive performance with pre-existing scores.

Background: The retrograde approach was introduced for recanalization of challenging CTOs.

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Epidemiological characteristics and prognostic profiles of patients with newly diagnosed coronary artery disease (CAD) are heterogeneous. Therefore, providing individualized cardiovascular (CV) risk stratification and tailored prevention is crucial. Phenotypic unsupervised clustering integrating clinical, coronary computed tomography angiography (CCTA), and cardiac magnetic resonance (CMR) data were used to unveil pathophysiological differences between subgroups of patients with newly diagnosed CAD.

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Background: Inducible ischaemia is a strong marker of vascular vulnerability. Knowing the important role of the vascular tropism of COVID-19 to explain its severity, the presence of a prior inducible ischaemia may be a key pathogenetic determinant of COVID-19 severity.

Aims: To investigate the prognostic value of prior inducible ischaemia on stress cardiovascular magnetic resonance (CMR) to predict death in patients hospitalized for COVID-19.

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Background: Vasospastic angina is an infrequent underlying cause of angina and is under-diagnosed. Ergonovine provocation tests can be performed via intravenous or intracoronary injections. Although the safety profile of intracoronary injection has been well documented, no study has yet compared the intracoronary and intravenous injections regarding the positivity rate of the test.

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Background: Although the benefit of coronary revascularization in patients with stable coronary disease is debated, data assessing the potential interest of stress cardiovascular magnetic resonance (CMR) to guide coronary revascularization are limited. We aimed to assess the long-term prognostic value of stress CMR-related coronary revascularization in consecutive patients from a large registry.

Methods: Between 2008 and 2018, a retrospective cohort study with a median follow-up of 6.

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Aims: To assess the sex-specific, long-term prognostic value of myocardial ischaemia induced by stress cardiovascular magnetic resonance (CMR) and early CMR-related revascularization in consecutive patients from a large registry.

Methods And Results: Between 2008 and 2010, all consecutive patients referred for stress CMR were followed for the occurrence of major adverse cardiovascular events (MACE), defined by cardiovascular mortality or recurrent non-fatal myocardial infarction (MI). Early CMR-related revascularization was defined as any revascularization within 90 days after CMR.

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Objectives: The objectives of this study were to investigate the long-term prognostic value of inducible myocardial ischemia assessed by vasodilator stress cardiovascular magnetic resonance (CMR) in patients with HFpEF.

Background: Some studies suggest that ischemia could play a key role in HF in patients with preserved ejection fraction (HFpEF).

Methods: Between 2008 and 2019, consecutive patients prospectively referred for stress CMR with HFpEF as defined by current guidelines, without known coronary artery disease (CAD), were followed for the occurrence of major adverse cardiovascular events (MACE), as defined by cardiovascular mortality or nonfatal myocardial infarction (MI).

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Background: Cardiovascular magnetic resonance imaging (CMR) is an accurate technique for assessing ventricular function, myocardial perfusion and viability; its development remains limited mainly because of logistical and time constraints. Data regarding optimization of a dedicated stress CMR workflow are needed.

Aims: This study aimed to describe the optimization of a dedicated workflow, and to assess the feasibility and safety of stress CMR in a large registry of>35,000 patients.

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Background: While current guidelines recommend noninvasive testing to detect coronary artery disease, stress tests are deemed inconclusive in a quarter of cases. The strategy for risk stratification after inconclusive stress testing is not well standardized. To assess the prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) parameters and CMR-based coronary revascularization in patients after inconclusive stress testing.

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