Effect of single and repeated oral doses of telithromycin on cardiac QT interval in healthy subjects.

Background: Telithromycin is the first member of a new class of antimicrobials-the ketolides. The main objective of this study was to assess the effect of various oral doses of telithromycin on QT interval during single and repeated administrations.

Methods: Seventeen men and 17 women participated in double-blind, placebo-controlled, crossover studies.