Publications by authors named "Stephan Patrick Rosshart"
Article Synopsis
- Early-life immune development is essential for long-term health, but the factors influencing postnatal immune maturation are not well understood.
- The study focused on mononuclear phagocytes in Peyer's patches, showing significant age-related changes that led to reduced T cell priming in young organisms.
- The research identified that the differentiation of follicle-associated epithelium M cells is crucial for driving the maturation of these immune cells after weaning.
Over the past decades, microbiome research has evolved rapidly and became a hot topic in basic, preclinical and clinical research, for the pharmaceutical industry and for the general public. With the help of new high-throughput sequencing technologies tremendous progress has been made in the characterization of host-microbiota interactions identifying the microbiome as a major factor shaping mammalian physiology. This development also led to the discovery of the gut-brain axis as the crucial connection between gut microbiota and the nervous system.
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- - The microbiome is a diverse ecosystem of microorganisms associated with hosts, significantly impacting mammalian physiology, especially the immune system, through millions of years of co-evolution.
- - Traditionally, research focused on gastrointestinal bacteria, but recent studies highlight the importance of other microbes, including viruses, fungi, and protozoa, challenging researchers to adopt a more holistic approach to microbiome studies.
- - This overview emphasizes the role of the entire microbiome in shaping immunity and health, urging a recognition of the systemic effects of non-bacterial microorganisms beyond just the gut.