Publications by authors named "Stephan L Leib"
Article Synopsis
- Listeria monocytogenes is a dangerous bacteria that can cause severe brain infections, particularly encephalitis, in ruminants like sheep, goats, and cattle, with differing outcomes among these animals.
- Researchers studied how the expression of iNOS (an enzyme associated with NO production) varied in the brains of these animals, finding that cattle showed the strongest presence of iNOS, which correlated with lower bacterial counts, while goats exhibited high bacterial loads despite low iNOS activity.
- A new animal model using infant rats reinforced the idea that NO is crucial in controlling Listeria infections, as treatment with specific inhibitors resulted in increased mortality and bacterial proliferation, indicating the importance of nitric oxide and the potential role of other reactive oxid