Publications by authors named "Stephan Frankenfeld"
In unilateral ureteral obstruction (UUO), both oxidative stress and mitochondrial dysfunction are related to cell death. The aim of this study has been to characterize profiles of enzyme antioxidant activities and mitochondrial functioning of the contralateral (CL) compared to UUO and Sham (false-operated) kidneys of Balb/c mice. Kidneys were resected 14 days after obstruction for immunohistochemical and cortical mitochondrial functioning assays.
View Article and Find Full Text PDFThe abuse of anabolic androgenic steroids (AAS) may cause side effects in several tissues. Oxidative stress is linked to the pathophysiology of most of these alterations, being involved in fibrosis, cellular proliferation, tumorigenesis, amongst others. Thus, the aim of this study was to determine the impact of supraphysiological doses of nandrolone decanoate (DECA) on the redox balance of liver, heart and kidney.
View Article and Find Full Text PDFArticle Synopsis
- Anabolic-androgenic steroid abuse is on the rise, with doses significantly higher than therapeutic levels (10- to 100-fold), leading to various side effects, particularly on glucose metabolism during fasting.
- This study focused on the effects of high doses of nandrolone decanoate (DECA) on glucose regulation in male Wistar rats, comparing low therapeutic doses to high supraphysiological doses over an 8-week period.
- Results showed that high doses of DECA led to increased insulin levels but reduced glucose uptake in skeletal muscle, decreased fasting serum glucose, and impaired gluconeogenesis, indicating major disruptions in glucose metabolism.
Purpose: Many adverse effects have been associated with abuse of anabolic-androgenic steroids (AAS), including disorders of the urogenital tract. The objective of this study is to analyze the morphological modifications in the prostate ventral lobe of pubertal and adult rats chronically treated with AAS, using morphometric methods.
Materials And Methods: We studied 39 male Wistar rats weighing between 400 g and 550 g.