Reactions of R3PNNPR3 species with Boranes: Classical Adducts, FLPs and Radical Cations.

Although the nature of bis-phosphazine species are of much interest, there are few reports of their reactivity. Herein, we show that the bis-phosphazine species Ph3PNNPPh31 react with Lewis acids to give the Lewis acid adducts Ph3PNN(B(C6F5)3)PPh33 and Ph3PN(BF3)N(BF3)PPh34. Compound 1 also generates a frustrated Lewis pair (FLP) in the presence of BPh3 and thermolysis of 1/BPh3, or 3 at 80 °C released N2 while 4 was stable at 80 °C.

Chitin-amended media: Improving efficacy of Cordyceps fumosorosea as a control agent of Cydia pomonella.

The microbial control of insect pests such as the codling moth Cydia pomonella is a major challenge in the apple industry. This study investigates the potential of chitin-amended media to improve the efficacy of the entomopathogenic fungus Cordyceps fumosorosea strain JKI-BI-1496 for control of C. pomonella.

Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial.

Background: In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has been indicated, the optimal dose is unknown. We aimed to assess efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.

Methods: RENOVE was a non-inferiority, investigator-initiated, multicentre, randomised, open-label, blinded endpoint trial done in 47 hospitals in France.

Photolytic and Thermal Reactions of [CH(PPh)(μ-N)] and Its Lewis Acid Adducts: N-N Bond Cleavage and Liberation of N.

The known species (PhP)N was previously described as two phosphine donors associated with a doubly Lewis acidic N-unit based on its thermal liberation of N. Herein, we prepare the related species [CH(PPh)(μ-N)] , where the chelation of the N fragment facilitates both N liberation and N-N bond cleavage reactions. In addition, these reactions can be achieved selectively via thermolysis of a Lewis acid adduct of or by direct photolysis, respectively.

Suppression of MT5-MMP Reveals Early Modulation of Alzheimer's Pathogenic Events in Primary Neuronal Cultures of 5xFAD Mice.

We previously reported that membrane-type 5-matrix metalloproteinase (MT5-MMP) deficiency not only reduces pathological hallmarks of Alzheimer's disease (AD) in 5xFAD (Tg) mice in vivo but also impairs interleukin-1 beta (IL-1β)-mediated neuroinflammation and Aβ production in primary Tg immature neural cell cultures after 11 days in vitro. We now investigate the effect of MT5-MMP on incipient pathogenic pathways that are activated in cortical primary cultures at 21-24 days in vitro (DIV), during which time neurons are organized into a functional mature network. Using wild-type (WT), MT5-MMP (MT5), 5xFAD (Tg), and 5xFADxMT5-MMP (TgMT5) mice, we generated primary neuronal cultures that were exposed to IL-1β and/or different proteolytic system inhibitors.

AI in Dental Radiology-Improving the Efficiency of Reporting With ChatGPT: Comparative Study.

Background: Structured and standardized documentation is critical for accurately recording diagnostic findings, treatment plans, and patient progress in health care. Manual documentation can be labor-intensive and error-prone, especially under time constraints, prompting interest in the potential of artificial intelligence (AI) to automate and optimize these processes, particularly in medical documentation.

Objective: This study aimed to assess the effectiveness of ChatGPT (OpenAI) in generating radiology reports from dental panoramic radiographs, comparing the performance of AI-generated reports with those manually created by dental students.

Synthesis and N-C bond cleavage reactions for cyclic phosphazenium dications.

Phosphazenium cations were first characterized 60 years ago and yet little is known of their reactivity. The bidentate phosphonium dicationic salts [(CH)(PPhF)][B(CF)]2 and [(CH)(PPhCl)][Cl]3 were prepared. Reaction of 2 with (MeSi)NMe gave the phosphazenium dication [(CH)(PPh)(μ-NMe)][B(CF)]4, while reaction of 3 with two equivalents of MeN(SiMe) gave the related dication [(CH)(PPhNMe)][Cl]5.

Reactions of 1,1- and 1,2-bis-boranes with a protic diamine and hydrazine.

The reactions of 1,1- and 1,2-bis-boranes, PhCHCH(B(CF))1 and MeSiCH(B(CF))CHB(CF)2, with -phenylenediamine and hydrazine are reported. The coordination of -phenylenediamine gives the expected adducts, PhCHCH(B(CF)(HN))CH4 and MeSiCH(B(CF))CHB(CF)((HN)CH) 6. Under thermal duress, 4 undergoes retrohydroboration, resulting in the reaction of the diamine with HB(CF) to give (CF)B(NH)(NH)CH5.

Reactivity of -(isocyanoimino)triphenylphosphorane toward group 13 Lewis acids.

The species PhPNNC 1 reacts with the group 13 Lewis acids E(CF) (E = B or Al), HB(CF), ClAl(CF) and ECl (E = Ga or In) to give the Lewis acid-base adduct PhPNNCB(CF) 2, the zwitterionic product (PhPNH)B(CF)CNB(CF)H 3, the chelated salts [(PhPNNC(CN)NPPh)ER][EXR] (E = Al, R = X = CF, 4; E = Al, R = CF, X = Cl, 5; E = Ga, R = X = Cl, 6), and the neutral species [(PhPNNC(CN)NPPh)InCl] 7. The nature of these variations in reactivity are rationalized and the potential utility considered.

First Results of Pediatric Robotic Inguinal Hernia Repair with the Senhance Surgical System: A Matched Cohort Study.

Introduction: Inguinal hernia repair (IHR) is one of the most common procedures in pediatric surgery. In children, the application of robotic surgery is limited, meaning safety and efficacy is still to be assessed. This report is the first one worldwide that describes inguinal hernia repair in children using the Senhance Surgical System (SSS).

Age-related Electrophysical Correlates of Cross-modal Attention Switching.

The human experience demands seamless attentional switches between sensory modalities. Aging raises questions about how declines in auditory and visual processing affect cross-modal attention switching. This study used a cued cross-modal attention-switching paradigm where visual and auditory stimuli were simultaneously presented on either spatially congruent or incongruent sides.

Design and characterization of geopolymer foams reinforced with fibres.

This paper presents the results of the optimisation and characterization of Miscanthus fibre reinforced geopolymer foams based on fly ash and represents an important step forward in the development of a sustainable and environmentally friendly insulation material. Miscanthus belongs to a promising group of renewable raw materials with favourable thermal insulation properties. Design of experiment (DoE) were used to optimize the thermal conductivity and compressive strength of e reinforced geopolymer foams.

Effects of volume management on free flap perfusion and metabolism in a large animal model study.

Free flap failure represents a substantial clinical burden. The role of intraoperative volume management remains controversial, with valid studies lacking. Here, using a large animal model, we investigated the influence of volume management on free flap perfusion and metabolism.

Correction: A chelated borinium cation.

Correction for 'A chelated borinium cation' by Christopher Major , , 2024, , 10075-10078, https://doi.org/10.1039/D4DT01242A.

Impact of aging on crossmodal attention switching.

Previous studies on crossmodal visual-auditory attention switching using a spatial discrimination task showed performance costs when the target modality changed relative to when it repeated. The present study (n = 42 for each age group) examined age-related changes in crossmodal attention switching by asking young (age range 19 to 30 years old) and older (age range 64 to 80 years old) participants to respond to unimodal central cues and bimodal lateralized stimuli. The participants' task was to indicate the location of the target in the relevant modality using button presses.

A chelated borinium cation.

Two coordinate boron cations are rare. Herein we report the synthesis of [RNSiMeCH]BF (R = Dipp 3, 1-Ad 5) (Dipp = CH(iPr), Ad = CH) the reaction of BF with the corresponding dilithiated diamides. Subsequent abstraction of fluoride provided the corresponding borinium salts, [(RNSiMeCH)B][B(CF)] (R = Dipp 6, 1-Ad 8).

Fluorination/Dearomatization of CF Groups: An FLP Route to an Electrophilic Borane and Non-Coordinating Anions.

B(CF) and the corresponding anion [B(CF)] are ubiquitous in main group and transition metal chemistry. Known derivatives are generally limited to the incorporation of electron donating substituents. Herein we describe electrophilic fluorination and dearomatization of such species using XeF in the presence of BF or Lewis acidic cations.

Home blood pressure measurement self-reporting in real-life practices using the Hy-Result app: self-monitoring and digital pathway.

Background: Little real-life information is available on the clinical characteristics of information and communication technologies (ICTs) users, particularly in the context of hypertension and home blood pressure measurement (HBPM). This retrospective observational study describes HBPM practices obtained through the Hy-Result system, a validated app designed to help patients perform HBPM and understand their results through an automatic interpretation of the readings using web interface.

Methods: We analyzed 19,176 HBPM reports (sequence of 1 to 7 days of measurements; 3 in the morning, 3 in the evening) collected in real life circumstances from two groups of users: primary care (Prim) and hypertension center (Hosp).

Investigation of the interface of fungal mycelium composite building materials by means of low-vacuum scanning electron microscopy.

Low-vacuum scanning electron microscopy (low-vacuum SEM) is widely used for different applications, such as the investigation of noncoated specimen or the observation of biological materials, which are not stable to high vacuum. In this study, the combination of mineral building materials (concrete or clay plaster) with a biological composite (fungal mycelium composite) by using low-vacuum SEM was investigated. Fungal biotechnology is increasingly gaining prominence in addressing the challenges of sustainability transformation.

Synthesis and Reactivity of the [NCCCO] Cyanoketenate Anion.

Cyanoketene is a fundamental molecule that is actively being searched for in the interstellar medium. Its deprotonated form (cyanoketenate) is a heterocumulene that is isoelectronic to carbon suboxide whose structure has been the subject of debate. However, the investigation of cyanoketene and its derivatives is hampered by the lack of practical synthetic routes to these compounds.

Triple -substitution reactions of B(CF) and [(CF)PF] with P(SiMe).

-Substitution reactions on CF rings of Lewis acids have been exploited to achieve triply substituted derivatives. The reaction of B(CF) with P(SiMe) ultimately affords the Lewis acid B(CFP(SiMe))1. This species binds Lewis bases affording the adducts LB(CFP(SiMe)) (L = MeCN 2, OPEt3, PMe4, PBu5) and reacts with LiMe to give the salt [Li][MeB(CFP(SiMe))]·3THF 6.

Voluntary task switching is affected by modality compatibility and preparation.

Cognitive task control can be examined in task-switching studies. Performance costs in task switches are usually smaller with compatible stimulus-response modality mappings (visual-manual and auditory-vocal) than with incompatible mappings (visual-vocal and auditory-manual). Modality compatibility describes the modality match of sensory input and of the anticipated response effect (e.

Boron diamide derivatives containing N-N and N-P molecular fragments.

The cationic and neutral boron-diamide precursors are employed to target the inclusion of N and N-P molecular fragments. The species (HCN(Dipp))BNH5, and (HCN(Dipp))BNH6 were prepared. While efforts to oxidize with [NO] gave mixtures of products, reactions with NH gave the salts [(HCN(Dipp))B(NHNH)][OSCF] 7 [(HCN(Dipp))B(NHNH)][OSCF] 8.

Addition and NN bond cleavage of diazo-compounds by phosphino-phosphenium cations.

The phosphino-phosphenium cation (PPC) [PhPPPh][GaCl] reacts as a frustrated Lewis pair to add across the NN bond of (BuOCN). In contrast, photolytical addition [PhClPPPh][GaCl] to (RN) results in cleavage of the NN bond affording [PhP(μ-NR)PPhCl][GaCl] (R = Ph 2, CHCl). While the chloride of 2 is replaced with N or CN reaction with MeSiN or BuNC respectively, reaction with (CF)BH effects ring opening to give [HN(Ph)PPh(μ-NPh)PPh][GaCl] 7.

The Lewis superacidic aluminium cation: [(NHC)Al(CF)].

The aluminium salt [(NHC)Al(tol)(CF)][B(CF)], (NHC = CH(N(iPrCH))) is shown to behave as a Lewis superacid as it abstracts fluoride from [SbF]. It also acts as a Lewis acid catalyst for hydrosilyation, hydrodefluorination and Friedel-Crafts reactions.