Publications by authors named "Stephan Binneboessel"
Article Synopsis
- Gravitational changes from micro- to hypergravity cause various adaptations in the human body, including muscular atrophy, immune impairment, and circulatory system alterations.
- This study observed nine individuals during a parabolic flight, resulting in 11 minutes of microgravity, and analyzed blood samples for changes in plasma proteins before and after the flight.
- Out of 2925 proteins analyzed, 251 showed significant changes, particularly in proteins related to vesicle organization and apoptosis, indicating important physiological alterations due to varying gravity conditions.
Article Synopsis
- Nearly half of astronauts experience "Spaceflight associated neuro-ocular syndrome" (SANS) after long-duration missions, with the exact causes still unclear.
- This study will involve healthy subjects undergoing parabolic flights that simulate microgravity to investigate changes in retinal blood circulation using advanced imaging techniques.
- By examining retinal vessel changes and measuring intra-ocular pressure during these flights, the research seeks to determine if these factors play a role in the development of SANS.
Article Synopsis
- COVID-19 in critically ill elderly patients with renal failure may face higher mortality rates when treated with cytokine absorption compared to those receiving only renal replacement therapy (RRT).
- A study analyzed data from ICU patients aged 70 and older, highlighting that cytokine absorption did not significantly impact long-term survival, specifically at three months after treatment.
- The findings suggest that the severity of the disease, as measured by the Sequential Organ Failure Assessment (SOFA) score, is a more critical factor in determining mortality than the use of cytokine absorption therapy.
Article Synopsis
- The study focused on critically ill COVID-19 patients aged 70 and older, comparing treatment outcomes between genders.
- Male patients tended to be fitter than females and received more aggressive interventions like tracheostomy and renal replacement therapy.
- However, there was no significant difference in 30-day mortality rates between male and female patients after considering factors like disease severity and frailty.
Article Synopsis
- Investigates how the Activities of Daily Living (ADL) affect 3-month mortality in critically ill elderly ICU patients with COVID-19.
- The study analyzed data from 2,359 ICU patients aged 70 and older and found that most had high independence in daily activities before hospitalization.
- Results showed that patients with frailty or disability had significantly higher mortality rates, and ADL scores were important for predicting outcomes, with disabled patients facing a greater risk of death even after adjusting for other factors.
- The findings highlight the importance of assessing both frailty and disability when determining prognosis for this vulnerable group.
Article Synopsis
- Harsh conditions in space, like weightlessness and radiation, can harm cardiovascular health, necessitating preventive cardiology for safe travel.
- Studies indicate that weightlessness causes fluid shifts and issues like neuro-ocular syndrome and neck vein thrombosis, risking crew health during and after missions.
- Preventive measures and early detection technologies will be essential for maintaining cardiovascular health in astronauts, especially with the increase of older individuals with heart risks in commercial space travel.
Article Synopsis
- The study evaluates the modified MELD-XI score to predict outcomes for critically ill patients over 70 with COVID-19, focusing on organ failure risk and mortality.
- Data were collected from nearly 3,000 ICU patients, revealing a significant correlation between higher MELD-XI scores and increased mortality rates at 30 days, in the ICU, and at three months post-admission.
- Findings indicate that the MELD-XI score is a useful predictor for early mortality outcome in this vulnerable population, emphasizing its importance in critical care settings.
Article Synopsis
- Early lactate clearance is a key metric for evaluating prognosis and treatment efficacy in sepsis, with patients showing >0% clearance potentially having better outcomes.
- The study analyzed 3,299 sepsis patients, comparing those with lactate clearance ≤0% (1,528 patients) to those with >0% (1,771 patients) using multilevel logistic regression to assess ICU mortality.
- Results indicated that patients with >0% lactate clearance had significantly lower organ failure scores and ICU mortality rates (14% vs. 32%), suggesting better overall prognosis and treatment response in this group.
Background: Profound knowledge about cardiovascular physiology in the setting of microgravity can help in the course of preparations for human space missions. So far, influences of microgravity on the cardiovascular system have been demonstrated, particularly pertaining to venous fluid shifts. Yet, little is known about the mechanisms of these adaptations on continuous macrocirculatory level and regarding the microcirculation.
View Article and Find Full Text PDFSublingual microcirculation detects impaired perfusion in dehydrated older patients.
Clin Hemorheol Microcirc
November 2020
Article Synopsis
- This study explores the feasibility of sublingual microcirculatory measurements in clinically dehydrated patients aged 65 and older.
- It finds that frailty and cognitive performance do not significantly impact video quality of microcirculation assessments.
- Additionally, the study reveals that dehydration results in impaired microcirculation, which improves after rehydration.
Objective: Diagnostic and risk stratification are limited in emergencies. The measurement of microcirculation might identify patients with poor perfusion but compensated macrocirculation such as in beginning shock. This proof-of-concept study examines whether sublingual prehospital sidestream dark-field microscopy is feasible.
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