Nursing research at German university hospitals: A descriptive, cross-sectional study on the current status of nursing research activities and challenges for ethical approval.

Introduction: Nursing research is an integral part of nursing science and essential for evidence-based nursing practice. Research conducted by nursing scientists employed at university hospitals is shaped by the specific prevailing conditions. It is largely unclear to what extent these nursing scientists are engaged in research and which difficulties they have to face.

Predictive Utility of Four Instrumental Activities of Daily Living Assessments and Cognitive Status Changes Among Cognitively In-Tact Older Adults.

Purpose: To examine the factor structure and predictive utility of four instrumental activities of daily living (IADL) measures to identify cognitive status changes among older adults enrolled in the ACTIVE Trial.

Major Findings: Extracted factors represented IADL instruments. Baseline performance on the Everyday Problems Test (EPT) predicted 5-year MMSE scores (est.

The ventral midline thalamus and long-term memory: What consolidation, what retrieval, what plasticity in rodents?

The ventral midline thalamus, including the reuniens and rhomboid (ReRh) nuclei, connects bidirectionally with the medial prefrontal cortex (mPFC) and hippocampus (Hip), both essential for memory processes. This review compiles and discusses studies on a role for the ReRh nuclei in the system consolidation of memories, also considering their potentially limited participation in memory retrieval or early phases of consolidation. It also examines scientific literature on short- and long-term plasticity in ReRh-mPFC and ReRh-Hip connections, emphasizing plasticity's importance in understanding these nuclei's role in memory.

Differential Longitudinal Associations Between Depressive Symptoms and Cognitive Status by Living Situation in Older Adults.

This study explores whether living situation modifies longitudinal associations between depressive symptoms and changes in cognitive status across ten years in generally healthy, community-dwelling older adults. Participants ( = 687, = 73.92 years) from the no-contact control condition of a multisite longitudinal study completed the Mini-Mental State Examination, Center for Epidemiological Studies Depression scale, and self-reported living situation.

Transgenic sensors reveal compartment-specific effects of aggregation-prone proteins on subcellular proteostasis during aging.

Loss of proteostasis is a hallmark of aging that underlies many age-related diseases. Different cell compartments experience distinctive challenges in maintaining protein quality control, but how aging regulates subcellular proteostasis remains underexplored. Here, by targeting the misfolding-prone Fluc luciferase to the cytoplasm, mitochondria, and nucleus, we established transgenic sensors to examine subcellular proteostasis in Drosophila.

Linear poly-ubiquitin remodels the proteome and influences hundreds of regulators in Drosophila.

Ubiquitin controls many cellular processes via its posttranslational conjugation onto substrates. Its use is highly variable due to its ability to form poly-ubiquitin chains with various topologies. Among them, linear chains have emerged as important regulators of immune responses and protein degradation.

Addressing relationship quality of people with dementia and their family carers: which profiles require most support?

Objective: The quality of the relationship between persons with dementia and family carers influences health and quality-of-life outcomes. Little is known regarding those at higher risk of experiencing a decline in relationship quality, who could potentially benefit the most from interventions. We aimed to identify these risk profiles and explore the underlying factors.

A novel mouse model reproducing frontal alterations related to the prodromal stage of dementia with LEWY bodies.

Background: Dementia with Lewy bodies (DLB) is the second most common age-related neurocognitive pathology after Alzheimer's disease. Animal models characterizing this disease are lacking and their development would ameliorate both the understanding of neuropathological mechanisms underlying DLB as well as the efficacy of pre-clinical studies tackling this disease.

Methods: We performed extensive phenotypic characterization of a transgenic mouse model overexpressing, most prominently in the dorsal hippocampus (DH) and frontal cortex (FC), wild-type form of the human α-synuclein gene (mThy1-hSNCA, 12 to 14-month-old males).

Consideration of inequalities in effectiveness trials of mHealth applications - a systematic assessment of studies from an umbrella review.

Background: The growing use of mobile health applications (apps) for managing diabetes and hypertension entails an increased need to understand their effectiveness among different population groups. It is unclear if efficacy and effectiveness trials currently provide evidence of differential effectiveness, and if they do, a summary of such evidence is missing. Our study identified to what extent sociocultural and socioeconomic inequalities were considered in effectiveness trials of mobile health apps in diabetic and hypertensive patients and if these inequalities moderated app effectiveness.

[Implementation of reference frameworks at nursing schools - A qualitative study on beneficial and hindering factors].

Background: The reference frameworks that have been developed for the first time by the Specialist Committee in accordance with Sect. 53 of the German Nursing Professions Act follow a new didactic-curricular structure and are intended to support the nursing schools in creating their own curricular documents.

Research Question/objective: The commissioned study investigated hindering and promoting factors in the implementation of reference frameworks at nursing schools.

Undergraduate students engaging in hands-on gerontology research: a participatory case study of value gained and lessons learned.

As the population ages, it is essential that professionals across disciplines have experience and competence working with older adults. Though experiential learning opportunities have been extensively documented as a tool to accomplish this goal, student engagement in gerontology research has not been examined in detail. This participatory case study highlights the perspectives of undergraduate student researchers involved in a hands-on pilot research study that explored connections between cognitive, physical, and everyday function in midlife and older adults while testing the feasibility of a mobile app for early detection of cognitive decline related to Alzheimer's disease and related dementias.

A systematic mapping of public health master's and structured doctoral programs in Germany.

Background: Well-trained public health professionals are key to addressing both global and local public health challenges of the twenty-first century. Though availability of programs has increased, the population health science (PHS) and public health (PH) higher education landscape in Germany remains scattered. To date, no comprehensive overview of programs exists.

Pain Medication and Pain Intensity Following Hip Fractures-Analyses Based on the ProFem Cohort Study.

Purpose: Pain is a common symptom following proximal femoral fractures (PFF), however, information on its treatment in terms of agents and type of use (scheduled vs. pro re nata [PRN]) is scarce. The main objective of this study was to examine pain medication regimens according to pain intensity following PFF.

The resisted torsional stress test in diagnosis of femoral stem loosening in uncemented total hip arthroplasty - first description and retrospective study.

Introduction: Aseptic femoral stem loosening is among the most common causes for revision in total hip arthroplasty (THA). We describe a simple clinical test that triggers pain in the proximal femur in patients with a loose stem. A previously described passive rotation test was associated with a poor sensitivity.

Older Adults' Perceptions of Cognitive, Physical, and Exergame Training: A Mixed Methods Investigation of a Four-Armed Randomized Controlled Pilot Trial.

Although the health benefits of behavioral interventions for older adults are well studied, research focused on intervention acceptability in older adult populations is less established and is needed. This mixed methods study investigated older adults' perceptions of training interventions. Community-dwelling older adults ( = 41) were randomized into three groups (cognitive, physical, and exergame) and completed 20 in-lab training sessions over 10 weeks.

In relentless pursuit of the white whale: A role for the ventral midline thalamus in behavioral flexibility and adaption?

The reuniens (Re) nucleus is located in the ventral midline thalamus. It has fostered increasing interest, not only for its participation in a variety of cognitive functions (e.g.

Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages.

Germ cell tumors (GCT) are the most common solid tumors in young men of age 15 - 40. In previous studies, we profiled the interaction of GCT cells with cells of the tumor microenvironment (TM), which showed that especially the 3D interaction of fibroblasts (FB) or macrophages with GCT cells influenced the growth behavior and cisplatin response as well as the transcriptome and secretome of the tumor cells, suggesting that the crosstalk of these cells with GCT cells is crucial for tumor progression and therapy outcome. In this study, we shed light on the mechanisms of activation of cancer-associated fibroblasts (CAF) in the GCT setting and their effects on GCT cells lines and the monocyte cell line THP-1.

TikTok misinformation and user engagement in female pelvic floor conditions.

Importance: Social media platforms are increasingly utilized to distribute medical information. Our study emphasizes the need for accuracy in pelvic health education on social media and the involvement of female pelvic floor (FPF) specialists in content creation.

Aims: In this cross-sectional study, we assessed the FPF TikTok videos with the highest engagement for quality of information and misinformation and investigated the relationship between misinformation and user engagement.

Development of Fear of Falling after proximal femoral fracture.

Proximal femoral fracture is common in older people. Beyond a long recovery process and significant permanent functional limitations, older people often experience subsequent Fear of Falling. The phenomenon of Fear of Falling is not fully understood; qualitative research is underrepresented but can provide insights into the experience of those affected.

Linear ubiquitin chains remodel the proteome and influence the levels of hundreds of regulators in .

Ubiquitin controls many cellular processes via its post-translational conjugation onto substrates. Its use is highly variable due to its ability to form poly-ubiquitin with various topologies. Among them, linear chains have emerged as important regulators of immune responses and protein degradation.

Shared EEG correlates between non-REM parasomnia experiences and dreams.

Sleepwalking and related parasomnias result from incomplete awakenings out of non-rapid eye movement sleep. Behavioral episodes can occur without consciousness or recollection, or in relation to dream-like experiences. To understand what accounts for these differences in consciousness and recall, here we recorded parasomnia episodes with high-density electroencephalography (EEG) and interviewed participants immediately afterward about their experiences.