Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine.

Flavonoids are polyphenolic compounds widely occurring throughout the plant kingdom. They are biologically active and have many medical applications. Flavonoids reveal chemopreventive, anticarcinogenic, and antioxidant properties, as well as being able to modulate the immune system response and inhibit inflammation, angiogenesis, and metastasis.

Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-][1,2,4]triazole-6(5)-ones as Possible Anticancer Agents.

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of -isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-]-[1,2,4]triazole-6-ones.