Publications by authors named "Stepan A Kremis"
Article Synopsis
- High biological activity of natural furocoumarins can lead to harmful side effects, like genotoxicity, making it important to develop safer semi-synthetic alternatives.
- The researchers previously examined twenty-one modified furocoumarins to find alterations that reduce negative effects while keeping or improving their beneficial properties.
- In this article, they focus on assessing the cytotoxic activity of these compounds, ranking them by severity, and using statistical analysis to identify the best modifications for future development.
The furocoumarin backbone is a promising platform for chemical modifications aimed at creating new pharmaceutical agents. However, the high level of biological activity of furocoumarins is associated with a number of negative effects. For example, some of the naturally occurring ones and their derivatives can show genotoxic and mutagenic properties as a result of their forming crosslinks with DNA molecules.
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