Diabetes and the associated complications: The role of antioxidants in diabetes therapy and care.

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood sugar levels (hyperglycemia). Poorly managed diabetes can lead to complications affecting multiple organ systems. Antioxidants play a crucial role in reducing oxidative stress caused by reactive oxygen species (ROS), primarily triggered by uncontrolled high blood sugar levels in diabetes.

The power of partnership: Strategies for pan-Canadian spread and scale of paramedics providing palliative care.

Paramedics and Palliative Care is an example of a promising practice ("pilot") that underwent successful spread and scale across Canada. Through the support of two pan-Canadian health organizations and concurrent evolution of the profession of paramedicine, this innovation has become integrated into practice. Evaluation of the innovation sites showed positive impact in all elements of the quintuple aim, and data from the expansion sites mirrors this success.

Economic evaluation of the "paramedics and palliative care: bringing vital services to Canadians" program compared to the status quo.

Objective: Based on programs implemented in 2011-2013 in three Canadian provinces to improve the support paramedics provide to people receiving palliative care, the Canadian Partnership Against Cancer and Healthcare Excellence Canada provided support and funding from 2018 to 2022 to spread this approach in Canada. The study objectives were to conduct an economic evaluation of "the Program" compared to the status quo.

Methods: A probabilistic decision analytic model was used to compare the expected costs, the quality-adjusted life years (QALYs) and the return on investment associated with the Program compared to the status quo from a publicly funded healthcare payer perspective.

Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy.

IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-phosphorylated inositol derivative that has been shown to exhibit many biological activities that accrue benefits in health and diseases (cancer, diabetes, renal lithiasis, cardiovascular diseases, etc.).

Effect of leaf extract on human promyelocytic leukemia cells subjected to oxidative stress.

Objectives: has beneficial properties. However, its cytotoxicity and antioxidative effects on human promyelocytic leukemia cells (HL60) deserve investigation. Therefore, the efficacy of its crude extracts in offsetting damage in HL60 cells subjected to oxidative stress was studied.

New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review.

Inositol, or myo-inositol, and associated analog molecules, including myo-inositol hexakisphosphate, are known to possess beneficial biomedical properties and are now being widely studied. The impact of these compounds in improving diabetic indices is significant, especially in light of the high cost of treating diabetes mellitus and associated disorders globally. It is theorized that, within ten years, the global population of people with the disease will reach 578 million individuals, with the cost of care projected to be approximately 2.

Effects of Leaf Extract on Human Promyelocytic Leukemia Cells Subjected to Oxidative Stress.

Oxidative stress is initiated by reactive oxygen species, the primary factor in many chronic diseases. possesses strong antioxidant properties due to the presence of various phytochemicals. In this study, we investigated the effect of leaf extract on markers of oxidative stress in HL60 cells exposed to oxidative stress.

Intervention assessment in an Indian health service pharmacy.

Objective: To document and evaluate pharmacists' interventions in a setting that has complete and immediate access to patient information.

Design: Descriptive report evaluating self-reported interventions made by pharmacists during the conduct of routine dispensing activities. The data collection period was from February 15 to April 1, 1994.

Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients.

Study Objective: To examine the effect of the concurrent administration of increasing amounts of grapefruit juice, an inhibitor of drug metabolism, on the steady-state pharmacokinetics of cyclosporine.

Design: Open-label, three-period crossover, food-drug interaction study in stable renal transplant patients.

Setting: A university-affiliated clinical research center.

Molecular basis of Alzheimer's disease.

Information on the molecular biology of Alzheimer's disease (AD) pointing to new methods of diagnosis and drug therapies is explored. AD is the most common cause of dementia in the elderly and is characterized by senile plaques and neurofibrillary tangles in the brain and loss of cholinergic neurons in the basal forebrain. The disease has a strong genetic component.

Extraction of diethylhexylphthalate from total nutrient solution-containing polyvinyl chloride bags.

Total nutrient solution (TNS) is a new method for delivering total parenteral nutrition (TPN) by admixing dextrose, amino acids, and lipids in a single container. Recommendations are to use nonpolyvinyl chloride (PVC) containers for admixture of these solutions. PVC is a hard, brittle, and inflexible substance, and plasticizers, predominantly diethylhexylphthalate (DEHP), are added to impart flexibility.

Evaluation of OTC self-medication reports as an instructional strategy for clinical education.

A novel instructional strategy for clinical education, the "Pharmacist Assisted Self-Medication Case Report," was introduced into a community practice externship in 1982. The purpose was to create an experimental tool which developed informational and problem solving skills of pharmacy students in the area of OTC self medication. The case report requires that the student conduct a patient interview, evaluate the patient's condition, decide on an appropriate recommendation and provide appropriate consultation.

Precipitate analysis from an indwelling total parenteral nutrition catheter.

The composition of a precipitate obtained from a silastic right atrial catheter was determined. The precipitate was collected and washed with deionized water thoroughly before subjecting portions of it to organic and inorganic analysis. Inorganic analysis was conducted using scanning electron microscopy and x-ray spectroscopy for sodium, aluminum, silicone, sulfur, chlorine, and calcium.

Sterility testing of home and inpatient parenteral nutrition solutions.

The microbial contamination rate was compared for parenteral nutrition solutions prepared by patients for home use and by pharmacy personnel for inpatient use. Phase I validated the Ivex 0.22-micron inline filter as a tool for microbiological testing by inoculating small numbers of organisms in 5% dextrose injection and testing for recovery.

Stability of levodopa in 5% dextrose injection at pH 5 or 6.

The stability of solutions of levodopa 1 mg/mL in 5% dextrose injection adjusted to pH 5 or 6 and stored at one of three temperatures was determined. Solutions were adjusted to pH 5 or 6 with sodium acetate injection or sodium phosphate injection, respectively. Three samples of solution adjusted to pH 5 were stored at each of three temperatures (4, 25, and 45 degrees C), and three samples of solution adjusted to pH 6 were stored at 25 degrees C.

Effects of pH, temperature, concentration, and time on particle counts in lipid-containing total parenteral nutrition admixtures.

It has been standard practice in the United States to separate lipid emulsion from the other components of total parenteral nutrition (TPN) due to the reported instability of admixed intravenous lipid emulsions. Some clinicians, however, have combined all TPN components into one container and administered these admixtures to patients without apparent difficulties. Infusion of all nutrients from one container has many advantages.

Description of an undergraduate sterile products clerkship.

A description of a ten week, full-time, elective sterile products clerkship designed for fifth year pharmacy students is presented. The course refines the student's written and oral communication skills and meets the NCCLVP standard for education of IV therapy personnel.

Stability of dopamine hydrochloride exposed to blue-light phototherapy.

The stability of dopamine hydrochloride in 5% dextrose injection when exposed to blue-light phototherapy was assessed. Solutions of dopamine hydrochloride (1000 micrograms/mL) were prepared, and samples were subjected to one of three light sources (fluorescent, dark, phototherapy) and two flow rates (2 mL/hr and no flow) at ambient room temperature. Irradiation levels were maintained between 5.

Stability of folic acid in 25% dextrose, 3.5% amino acids, and multivitamin solution.

The chemical stability of folic acid in 25% dextrose, 3.5% amino acids, and multivitamin solution was investigated. Solutions of 0.

Eleven years of experience with capitation reimbursement for pharmacy services.

Pharmacy services encompass more than dispensing medications. However, traditional pharmacy reimbursement methods are based heavily on the dispensing of medications--i.e.