Prolonged magnesium deficiency causes osteoporosis in the rat.

Background: Peroral magnesium (Mg) administration, used as the only treatment in postmenopausal osteoporosis, has been shown to cause a significant increase of BD.

Objectives: To gauge the role of magnesium deficiency in the etiology of osteoporosis, we compared rats fed a Mg deficient diet daily with rats fed a Mg adequate diet over a period of one year.

Methods: Sprague-Dawley female rats (mean weight 110, SD 23 g) were divided into two groups of 8 and randomly assigned to an identical semisynthetic diet, containing either 2000 ppm (group A) or 200 ppm Mg (group B).

Experimentally induced prolonged magnesium deficiency causes osteoporosis in the rat.

Background: It has been shown that prolonged daily peroral magnesium (Mg) administration, as tabs of Mg(OH)(2), used as the only treatment in postmenopausal osteoporosis, causes a significant increase in BMD. Objective: In order to obtain definitive evidence of causality of magnesium deficiency in the etiology of osteoporosis, we spent 1 year examining rats given a daily Mg-deficient diet (200 ppm) and compared them with rats given a Mg-adequate diet (2000 ppm). Methods: Sixteen female Sprague-Dawley rats, mean weight 110 (S.

How significant is magnesium in thermoregulation?

Nine apparently healthy male subjects, mean age 22.8 yr, SD 4.1, free from disease, medication or addiction who gave informed consent, underwent acclimation process in a heat chamber; exposed during 2 h daily for 10 consecutive days to a temperature of 40 degrees C and 40% relative humidity while walking on a treadmill elevated by 3 degrees at a speed of 5 km/h (VO2 1.

Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis.

Since magnesium regulates calcium transport, and magnesium replacement in magnesium-deficient postmenopausal patients resulted in unexpected improvement in documented osteoporosis, we investigated the effect of magnesium treatment on trabecular bone density in postmenopausal osteoporosis. Thirty-one postmenopausal patients (mean age +/- SD = 57.6 +/- 10.

Sudden death of athletes: is it due to long-term changes in serum magnesium, lipids and blood sugar?

In young, apparently healthy, trained Israeli men, strenuous effort was reported to give rise to persistent magnesium (Mg) deficiency and a parallel long-term increase of cholesterol, triglycerides and blood sugar parallel 1-3. The relationship of Mg deficiency to the pathogenesis of cardiovascular disease has been increasingly documented during the last decade. Several authors have highlighted the phenomenon of sudden deaths in sport and have suggested that it is associated with cardiovascular disease.

Is physical working capacity determined by optimal magnesium concentration?

Two lines of research originated in the mid-seventies; one attempted to gauge the effect of strenuous effort on serum magnesium concentration (S-Mg) and the second, the effect of S-Mg on the indices of physical working capacity. In apparently healthy trained young Israeli men, long-term studies of the effect of strenuous effort on S-Mg showed that after a moderately strenuous effort (70 km forced march), there was a decrease of S-Mg which became statistically significant after 72 h, whereas after a severely strenuous effort (120 km forced march), the decrease was biphasic, being significant after 1 h, with a second fall after 72 h. In repeated experiments, the decrease of S-Mg was found to persist over time parallel 1.

Magnesium content of mononuclear cells, erythrocytes and 24-hour urine in carefully screened apparently healthy Israelis.

Twenty apparently healthy Israelis aged 16-52, examined for their history of disease and, carefully screened to exclude concurrent infection or medication, abuse of alcohol or drugs, and pathological findings on routine laboratory estimation, were examined to establish the reference range for the magnesium content of mononuclear cells. The magnesium content of mononuclear cells was estimated according to modified method of Elin & Hosseini (Clin. Chem.

Long term effects of peak strenuous effort on serum magnesium, lipids, and blood sugar in apparently healthy young men.

Earlier findings showed a sustained lowering of serum magnesium concentration (S-Mg) which indicated the presence of Mg deficit, and a parallel, delayed rise of blood sugar and serum lipids as a sequel to strenuous effort. S-Mg was still significantly decreased 3 months after termination of peak effort. To gain further perspective, we followed the biochemical sequels of exertion over an extended period of observation, while maintaining the same experimental conditions used earlier, which mimicked those employed in the training of military recruits.

Delayed metabolic changes after strenuous exertion in trained young men.

Twenty apparently healthy, young male volunteers, aged 18-25 (mean 19.3, SD 1.4) years received a 6 months standardized, graded outdoor physical training and were screened for serum magnesium concentration (S-Mg), serum calcium concentration (S-Ca), serum aspartate amino transferase (S-AST), serum alanine amino transferase (S-ALT), serum creatine kinase activity (S-CK), other laboratory variables, weight, and VO2 ml.

Magnesium fluxes in ventricular fibrillation and defibrillation in untreated and dibenzepine HC1 pretreated cats.

Serum magnesium concentration (S-Mg) was estimated in 12 anesthetized cats before and after central thoracotomy, during an electrically induced ventricular fibrillation (VF) and after defibrillation (DEF), and again, in the same experimental animals, after the administration of 3 mg/kg of dibenzepine HC1--a tricyclic antidepressant reported to facilitate spontaneous DEF--as well as during a subsequently induced VF and after the spontaneous DEF which followed. In the first part of the experiment, the surgery and the induction of VF caused no significant change of mean serum magnesium concentration (S-Mg) or serum calcium concentration (S-Ca), whereas the DEF was accompanied by Mg efflux (a significant increase of mean S-Mg from 0.824 mmol/l, SD 0.

Changes in serum magnesium concentration after strenuous exercise.

Serum magnesium concentration (S-Mg) was measured in 20 highly trained young men (mean age 19.5, +/- 0.5, range 18-20.

Comparison of diluents for serum magnesium estimation by atomic absorption spectrophotometry.

In order to determine the optimal diluent for the determination of Mg by atomic absorption spectrophotometry, the following diluents were tested: deionized water, 0.1 mol/l HCl, 2.5 g/l SrCl2, 1.

Stepwise regression analysis of an intensive 1-year study of delirium tremens.

An intensive 1-year study was carried out on 41 male patients, mean age 49, mean hospitalization time 49 days, admitted to a special ward of the Beckomberga Hospital with the diagnosis of delirium tremens and 50 concomitant somatic and psychiatric diagnoses (1--9 per capita), and given a standardized treatment. The mean duration of delirium tremens after admission was 2 days; 76% recovered within 48 h. The duration after admission was positively correlated to age, number of previous delirium tremens, negatively correlated to B-haemoglobin and B-haematocrit for laboratory data obtained within the first 24 h and was positively correlated to blood sugar and S-creatinine on data taken within 40 h (Pearson correlation matrix).

Hypomagnesaemia and muscle electrolytes and metabolites.

Ten patients, aged 39-61 years, with hypomagnesaemia due to chronic alcoholism (7 cases) or malabsorption (3 cases), have been investigated by assessing the maximum isometric voluntary contraction force (MVC) of the quadriceps femoris muscle (7 cases), laboratory screening (9 cases) and estimating the electrolyte and metabolite content of biopsy specimens from the quadriceps femoris muscle. The MVC ranged from 0.5 to 34 kp and was significantly lower than in 12 apparently healthy normomagnesaemic controls (p is less than 0.