Influence of preseasonal treatment with L-tyrosine-adsorbed allergoids on IgE-mediated histamine release from basophils of children suffering from allergic diseases.

In 10 children suffering from allergic pollinosis and/or asthma, a preseasonal hyposensitization scheme with 3 weekly injections of a glutaraldehyde-modified, tyrosine-adsorbed grass-pollen allergen reduced the histamine release from basophils in response to increasing concentrations of antigen. The decrease in histamine release which occurred 1 week after the injection course was even maintained during the pollen season. The inhibition was only obtained when basophils were incubated with the serum of patients, but not with the serum of normals, indicating that blocking antibodies may have occurred.

Comparison of the effects of theophylline, prednisolone and sleep withdrawal on airway obstruction and urinary cyclic AMP/cyclic GMP excretion of asthmatic children with and without nocturnal asthma.

Asthmatic children suffering from nocturnal asthmatic paroxysms showed not only a reduced peak exspiratory flow rate (PEER) but also a diminished excretion of cyclic AMP (cAMP) at night. In contrast, in asthmatic children without nocturnal asthmatic attacks, neither in PEFR nor in cAMP excretion did a circadian rhythm occur. Prednisolone, theophylline, and sleep withdrawal were able to reestablish normal airway function and cAMP excretion in those patients with nocturnal bronchoconstriction.

[Salbutamol in asthmatic children, lung function and plasma levels of free salbutamol after treatment with salbutamol rectally and by pressurized aerosol (author's transl)].

In 10 children with asthma bronchiale aged 4 10/12--14 3/12 years, Salbutamol was given rectally and by pressurized aerosol. After 1 h plasma concentration of free salbutamol and lung function were measured. Plasma concentrations of free salbutamol ranged between 1.

[Oral desensitization in childhood (author's transl)].

1) There is some evidence that orally administered allergens are absorbed. 2) 75% of the children considered oral desensitization to be effective. 3) As judged by bronchial flow resistance after provocation, oral and subcutaneous desensitization appear to be equally effective in reducing bronchial hypersensitivity.

[Monitoring heart frequency (beat to beat) and excursions of the thoracic wall--cardiorespirography--during exchange transfusion in newborn (author's transl)].

Heart rate (calculated beat to beat) and excursions of the thoracic wall were registered continuously during exchange transfusions in the newborn period (N equals 29). Short time changes of heart rate ranging from 5 to 10 (N equals 11) and from 11 to 25 beats per minute (N equals 11) were usually present before exchange transfusion. In two cases "silent" (i.