Publications by authors named "Stella Youssafi"
In vitro validation concept for lyophilized fecal microbiota products with a focus on bacterial viability.
World J Microbiol Biotechnol
February 2025
Fecal microbiota transplantation (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), typically administered as a fresh or frozen stool suspension through colonoscopy, nasojejunal tube, or oral capsules. Lyophilized fecal microbiota (LFM) are an alternative to frozen FM products. We aimed to assess whether lyophilization affects bacterial viability and metabolite levels and to develop LFM capsules for clinical use in Germany.
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- Mammalian prions are infectious proteins formed from misfolded variants of the normal prion protein (PrP), exhibiting different conformations that can self-propagate and cause various prion diseases.
- Research demonstrates that fibrillar assemblies from recombinant PrP (rPrP) derived from various species (hamster, mouse, human, and bovine) show distinct pathogenic behaviors and strain properties when tested in transgenic mice.
- The findings indicate that rPrP assemblies can be used to study the transmission of prions and their strain diversity, as they can mimic the adaptation processes of genuine prions despite lacking certain crucial amino acid regions for infectivity.