Publications by authors named "Stella M Dieguez"
Protein loads in normal subjects increase glomerular filtration rate (GFR), which implies a renal functional reserve (RFR). Patients who have suffered a loss in the number of nephrons may show normal values of GFR due to hyperfiltration of remnant nephrons, with subsequent loss of RFR. This could be an early sign of renal damage, and probably a contributory factor to renal damage progress.
View Article and Find Full Text PDFEffect of chronic inhibition of converting enzyme on proximal tubule acidification.
Am J Physiol Regul Integr Comp Physiol
June 2008
Article Synopsis
- The study investigates the chronic effects of angiotensin-converting enzyme inhibition (ACEi) on proximal convoluted tubule (PCT) acidification by examining rats treated with enalapril for three months.
- Chronic treatment with enalapril led to a significant increase (about 50%) in bicarbonate transport (J(HCO(3)(-))), coupled with enhanced nitric oxide synthesis in the kidney.
- Inhibition of nitric oxide synthesis negated the acidification benefits from enalapril, indicating a crucial role of nitric oxide in this process, while key transport proteins remained unchanged.