Publications by authors named "Stella G Whang"
Background And Aims: Gastric intestinal metaplasia (GIM) is an important precursor lesion to gastric cancer (GC), the second leading cause of cancer death worldwide. There exist few data regarding the prevalence of, risk factors for, and clinical practice patterns regarding GIM in the United States. Furthermore, there are currently no U.
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- - The study examines how the rate of environmental change impacts the adaptation of populations, using the lytic RNA bacteriophage Φ6 as a model system exposed to varying rates of heat shocks to improve thermostability.
- - Results revealed that populations gradually exposed to higher temperatures showed better survival rates during initial heat exposure compared to those facing rapid increases in temperature.
- - While certain mutations enhanced viral thermostability, others improved growth rates, indicating that different selective pressures can affect adaptation outcomes in evolving environments.
Purpose: The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate of just 8%. Here, we evaluate the ability to enhance targeted drug delivery using mild hyperthermia in combination with the systemic administration of a low-temperature sensitive liposomal formulation of doxorubicin (LTSL-Dox) using a relevant model for pancreas cancer.
Materials And Methods: Experiments were performed in a genetically engineered mouse model of pancreatic cancer (KPC mice: LSL-Kras; LSL-Trp53; Pdx-1-Cre).