Psychosocial, psychopharmacological and demographic predictors of changes in psychological distress over a course of computerised cognitive behavioural therapy (cCBT).

Social group identification, socioeconomic deprivation, and a number of other clinical and demographic factors have been found to predict severity of psychological distress prior to treatment in those referred to receive computerised cognitive behavioural therapy (cCBT) as an intervention for mild to moderate depression. The aim of the current study is to investigate whether the same key factors are able to predict in psychological distress across treatment in a sample receiving cCBT. Participants ( = 1158) consisted of individuals completing the 'Beating the Blues' (BtB) programme.

Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011.

Background: Regulatory risk communications are an important method for disseminating drug safety information, but their impact varies. Two significant UK risk communications about antipsychotic use in older people with dementia were issued in 2004 and 2009. These varied considerably in their content and dissemination, allowing examination of their differential impact.

An observational study of psychotropic drug use and initiation in older patients resident in their own home or in care.

Objective: to compare the prescription of psychotropic medications for patients living in care homes with that for patients living at home.

Design And Setting: retrospective population database study in the Tayside region of Scotland.

Subjects: 70,297 patients aged ≥65 and followed until death or the end of the study.

The burden of psychotropic drug prescribingin people with dementia: a populationdatabase study.

Objective: to compare psychotropic prescribing in older people with dementia and the general elderly population.

Design And Setting: retrospective population database study in 315 General Practices.

Subjects: there were 271,365 patients aged > or = 65, of which 10,058 (3.

Cost (non)-recovery by platform technology facilities in the Bio21 Cluster.

Platform technologies (PT) are techniques or tools that enable a range of scientific investigations and are critical to today's advanced technology research environment. Once installed, they require specialized staff for their operations, who in turn, provide expertise to researchers in designing appropriate experiments. Through this pipeline, research outputs are raised to the benefit of the researcher and the host institution.

Predictors of discharge destination for 234 patients admitted to a combined geriatric medicine/old age psychiatry unit.

Objective: To examine the factors that predicted discharge destinations of all patients admitted to a combined geriatric medicine/old age psychiatry unit over a 4-year period.

Method: Data regarding discharge destinations, active medical problems and demographics of 234 patients admitted to the unit were analysed using non-parametric bivariate correlation and logistic regression analysis.

Results: Independence for activities of daily living (ADL) was the key predictor of discharge destination.

A randomised controlled trial of cognitive behaviour therapy vs treatment as usual in the treatment of mild to moderate late life depression.

Objectives: This study provides an empirical evaluation of Cognitive Behaviour Therapy (CBT) alone vs Treatment as usual (TAU) alone (generally pharmacotherapy) for late life depression in a UK primary care setting.

Method: General Practitioners in Fife and Glasgow referred 114 Participants to the study with 44 meeting inclusion criteria and 40 participants providing data that permitted analysis. All participants had a diagnosis of mild to moderate Major Depressive Episode.

Activation of PI 3-kinase by the hexosamine biosynthesis pathway.

It has been shown that hyperglycaemia-induced defects in glucose transport and insulin action are mediated by increased flux of excess glucose through the hexosamine biosynthesis pathway (HBP). We have previously demonstrated that in rat adipocytes, increased flux through the HBP activates protein kinase C (PKC). The aim of the present study was to explore the mechanism for HBP-mediated activation of PKC.