Publications by authors named "Stella A Belonwu"
Alzheimer's Disease (AD) is a complex neurodegenerative disease that gravely affects patients and imposes an immense burden on caregivers. Apolipoprotein E4 (APOE4) has been identified as the most common genetic risk factor for AD, yet the molecular mechanisms connecting APOE4 to AD are not well understood. Past transcriptomic analyses in AD have revealed genotype-specific transcriptomic differences; however, these differences have not been explored at a single-cell level.
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- Alzheimer's disease (AD) mainly impacts women and shows different neural anatomy and disease mechanisms based on sex, suggesting the need for tailored therapeutic approaches.
- Previous studies using bulk RNA sequencing identified sex-based differences in molecular pathways related to energy, neurons, and immune response but lacked detailed analysis at the single-cell level.
- By analyzing nearly 74,000 cells from human brain samples, we found significant sex differences in glial cells in the prefrontal cortex and opposing gene fluctuations in the entorhinal cortex between sexes in AD, highlighting the importance of considering sex in AD research for better treatment development.