[Diagnostic and prognostic significance of some laboratory indices of cerebrospinal fluid in multiple myeloma].

beta 2-microglobulin (beta 2-m) and certain other characteristics of liquor have been followed in the course of multiple myeloma (MM) versus severity of the disease and its response to chemotherapy, to establish the diagnostic and prognostic value of these indices. Lymphocytes and plasma cells were found in most of 17 patients under study, who were resistant to chemotherapy and relapsed; they revealed regular rise in liquor pressure and cytosis. Similarly, raised concentrations of beta 2-m were registered.

[Prognostic value of some biochemical and immunologic factors in the management of multiple myeloma].

The results of examination of 58 patients in the course of multiple myeloma (MM) are discussed. Prognosis for LDH, beta2-m and FNO-alpha administration was evaluated versus immunochemical pattern, tumor mass and response to different chemotherapeutic regimens. High prognostic value of serum levels of LDH, beta2 and FNO-alpha in MM patients was observed.

[Effect of various chemotherapy regimens on survival and cause of death in patients with multiple myeloma (retrospective study)].

A retrospective analysis of survival time and causes of death has been undertaken in 109 patients treated for multiple myeloma (MM) at the Hematologic Clinic of the Russian Research Institute of Hematology and Transfusiology in 1979-1995. Group I included cases of mono- and group II-polychemotherapy (PCT). Survival in patients with MM increased significantly (from 27 to 43 months) after PCT.

[The prognostic significance of the beta 2-microglobulin level of the blood serum in multiple myeloma patients].

Pretreatment and treatment content of beta 2-microglobulin in blood serum was measured in 52 patients with multiple myeloma stage IIA, IIB, IIIA and IIIB. The above concentrations before treatment correlated with the disease stage, rose in the exacerbation, remained unchanged in stabilization, fell in effective therapy and returned to normal values in remission. However, in pronounced renal insufficiency (stage IIIB) the remission beta 2-microglobulin levels remained high.

[Characteristics of the expression of the Ap- and Tc-genes of plasmid origin in lambda vectors].

Expression of Ap and Tc genes of the plasmid origin in lambda vectors where the effect of lac promoter and PL phage promoter can be traced has been studied. The different orientation of Ap gene relative to strong promoters (lac and PL) permitted the beneficial arrangement of Ap gene for its optimum expression to be established. The interfering interaction of the two closely arranged strong promoters, Ap gene and lac promoter, has been detected.