When the wild things are: Defining mammalian diel activity and plasticity.

Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental to understanding species behavior. However, we lack data and a standardized framework to accurately assess and compare temporal activity for species during rapid ecological change. Through a global network representing 38 countries, we leveraged 8.

Mapping threatened Thai bovids provides opportunities for improved conservation outcomes in Asia.

Wild bovids provide important ecosystem functions as seed dispersers and vegetation modifiers. Five wild bovids remain in Thailand: gaur (), banteng (), wild water buffalo (), mainland serow () and Chinese goral (). Their populations and habitats have declined substantially and become fragmented by land-use change.

CamTrapAsia: A dataset of tropical forest vertebrate communities from 239 camera trapping studies.

Information on tropical Asian vertebrates has traditionally been sparse, particularly when it comes to cryptic species inhabiting the dense forests of the region. Vertebrate populations are declining globally due to land-use change and hunting, the latter frequently referred as "defaunation." This is especially true in tropical Asia where there is extensive land-use change and high human densities.

Nature 4.0: A networked sensor system for integrated biodiversity monitoring.

Ecosystem functions and services are severely threatened by unprecedented global loss in biodiversity. To counteract these trends, it is essential to develop systems to monitor changes in biodiversity for planning, evaluating, and implementing conservation and mitigation actions. However, the implementation of monitoring systems suffers from a trade-off between grain (i.

Consistent patterns of common species across tropical tree communities.

Trees structure the Earth's most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge.

Livestock waste management for energy recovery in Brazil: a life cycle assessment approach.

Livestock farming has exerted intense environmental pressure on our planet. The high emissions to the environment and the high demands of resources for the production process have encouraged the search for decarbonization and circularity in the livestock sector. In this context, the objective of this study was to evaluate and compare the environmental performance of two different uses for biogas generated in the anaerobic digestion of animal waste, either for electricity generation or biomethane.

Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling.

High levels of circulating catecholamines cause cardiac injury, pathological remodeling, and heart failure, but the underlying mechanisms remain elusive. Here we provide both in vitro and in vivo evidence that excessive β-adrenergic stimulation induces ferroptosis in cardiomyocytes, revealing a novel mechanism for catecholamine-induced cardiotoxicity and remodeling. We found that isoproterenol, a synthetic catecholamine, promoted glutathione depletion and glutathione peroxidase 4 (GPX4) degradation in cardiomyocytes, leading to GPX4 inactivation and enhanced lipid peroxidation.

Opioid Use After Knee Arthroscopy in Adolescent Patients: A Prospective Evaluation.

Background: There is a relative paucity of literature on how to best treat postoperative pain after knee arthroscopy in the adolescent population.

Purpose: To evaluate the use of opioid medication after knee arthroscopy in adolescent patients.

Study Design: Case series; Level of evidence, 4.

A novel polymer-conjugated human IL-15 improves efficacy of CD19-targeted CAR T-cell immunotherapy.

Chimeric antigen receptor (CAR)-modified T-cell therapies targeting CD19 represent a new treatment option for patients with relapsed/refractory (R/R) B-cell malignancies. However, CAR T-cell therapy fails to elicit durable responses in a significant fraction of patients. Limited in vivo proliferation and survival of infused CAR T cells are key causes of failure.

Stress Radiography Is a Reliable Method to Quantify Posterior Cruciate Ligament Insufficiency: A Systematic Review.

Purpose: To perform a systematic review of posterior tibial stress radiography techniques and radiographic measurement methods to compare their accuracy and efficacy to aid clinicians in quantifying posterior cruciate ligament laxity.

Methods: Electronic databases, including PubMed, MEDLINE, Embase.com 1947- , Ovid Medline 1946- , Scopus 1823- , Cochrane Central Register of Controlled Trials (CENTRAL), and Clinicaltrials.

Swine manure treatment technologies as drivers for circular economy in agribusiness: A techno-economic and life cycle assessment approach.

Anaerobic digestion has been employed as a technology capable of adding value to waste coupled with environmental impact mitigation. However, many issues need to be elucidated to ensure the systems viability based on this technology. In this sense, the present study evaluated technically, environmentally, and economically, four configurations of swine waste treatment systems focused on the promotion of decarbonization and circularity of the swine chain.

The potential of animal manure management pathways toward a circular economy: a bibliometric analysis.

Improper disposal of animal waste is responsible for several environmental problems, causing eutrophication of lakes and rivers, nutrient overload in the soil, and the spread of pathogenic organisms. Despite the potential to cause adverse ecological damage, animal waste can be a valuable source of resources if incorporated into a circular concept. In this sense, new approaches focused on recovery and reuse as substitutes for traditional processes based on removing contaminants in animal manure have gained attention from the scientific community.

Global Variation in Studies of Articular Cartilage Procedures of the Knee: A Systematic Review.

Objective: The objective of this study was to determine whether there are significant differences in terms of indications, techniques, patient variables, and objective and subjective outcome scores as a function of the geographic locale of published studies of knee articular cartilage surgery.

Methods: An electronic database search was performed of clinical studies evaluating knee articular cartilage procedures from 2000 to 2021. Studies were separated into global regions (Europe, Asia, North America, and South America) based on the study country.

Return to play following nonsurgical management of superior labrum anterior-posterior tears: a systematic review.

Background: Superior labrum anterior-posterior (SLAP) tears are common shoulder injuries, especially in overhead athletes. Often, initial management of these injuries is nonsurgical with focused rehabilitation. The purpose of this review was to evaluate the outcomes of nonsurgical management of SLAP tears in athletes.

TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.

Mutations in TGF-β-activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are currently unknown. Here, we identified an indispensable role for TAB2 in regulating myocardial homeostasis and remodeling by suppressing receptor-interacting protein kinase 1 (RIPK1) activation and RIPK1-dependent apoptosis and necroptosis. Cardiomyocyte-specific deletion of Tab2 in mice triggered dilated cardiomyopathy with massive apoptotic and necroptotic cell death.

Meniscal Ramp Lesions: Anatomy, Epidemiology, Diagnosis, and Treatment.

Injuries to the medial meniscus meniscocapsular junction, also known as ramp lesions, are common in the setting of anterior cruciate ligament injuries with a prevalence of 9% to 42%. Anatomically, ramp lesions involve disruption of the posterior meniscocapsular junction and meniscotibial ligaments. Biomechanically, ramp lesions are associated with an increase in anterior tibial translation and internal and external tibial rotation in anterior cruciate ligament-deficient cadaveric knees.

Integration of swine manure anaerobic digestion and digestate nutrients removal/recovery under a circular economy concept.

The application of the circular economy concept should utilize the cycles of nature to preserve materials, energy and nutrients for economic use. A full-scale pig farm plant was developed and validated, showing how it is possible to integrate a circular economy concept into a wastewater treatment system capable of recovering energy, nutrients and enabling water reuse. A low-cost swine wastewater treatment system consisting of several treatment modules such as solid-liquid separation, anaerobic digestion, biological nitrogen removal by nitrification/denitrification and physicochemical phosphorus removal and recovery was able to generate 1880.

Phycoremediation and biomass production from high strong swine wastewater for biogas generation improvement: An integrated bioprocess.

This study investigated the phycoremediation process from swine digestate integrated with photosynthetic biomass and biogas production in the context of circular economy. Effects of total ammonia nitrogen (TAN) and pH on biomass productivity and nutrients removal, using a central rotational composite design, were evaluated. pH showed a significant effect on biomass productivity and phosphate removal.

Production of biofuels from soybean straw and hull hydrolysates obtained by subcritical water hydrolysis.

The objective of this study was to evaluate the ethanol production by Wickerhamomyces sp. using soybean straw and hull hydrolysates obtained by subcritical water hydrolysis and, afterward, the biogas production using the fermented hydrolysates. Ethanol was produced using the straw and hull hydrolysates diluted and supplement with glucose, reaching 5.

Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection.

Purpose: To describe the clinical course and microbial properties of the first two reported cases of nutritionally variant Streptococci ( and ) endophthalmitis following intravitreal anti-vascular endothelial growth factor injection (IVI).

Observations: A 74 year-old female developed endophthalmitis following IVI. The patient underwent a pars plana vitrectomy and visual acuity recovered to 20/30 in six weeks.

Septic arthritis of the acromioclavicular joint: a case series and review of the literature.

Objective: To report a case series of three patients with septic arthritis of the acromioclavicular joint and a review of the literature for this condition. Additionally, we developed an algorithm for diagnosing and treating septic arthritis of the acromioclavicular joint.

Methods: A retrospective review of patients treated at our institution for septic arthritis of the acromioclavicular joint during the collection period was performed and three cases were identified.

NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway.

In this study, we identified an unexpected pro-cell death role for NFκB in mediating oxidative stress-induced necrosis, and provide new mechanistic evidence that NFκB, in cooperation with HDAC3, negatively regulates Nrf2-ARE anti-oxidative signaling through transcriptional silencing. We showed that genetic inactivation of NFκB-p65 inhibited, whereas activation of NFκB promoted, oxidative stress-induced cell death and HMGB1 release, a biomarker of necrosis. Moreover, NFκB-luciferase activity was elevated in cardiomyocytes after simulated ischemia/reperfusion (sI/R) or doxorubicin (DOX) treatment, and inhibition of NFκB with Ad-p65-shRNA or Ad-IκBαM diminished sI/R- and DOX-induced cell death and HMGB1 release.

Effect of Tranexamic Acid on Wound Complications and Blood Loss in Total Ankle Arthroplasty.

Background: Tranexamic acid (TXA) is a medication that has been shown to decrease blood loss and risk of blood transfusion in total knee and total hip arthroplasty. The purpose of this study was to evaluate the use of TXA in patients undergoing total ankle arthroplasty (TAA). We hypothesized there would be less blood loss and wound complications in patients receiving TXA.

The effects of prey depletion on dietary niches of sympatric apex predators in Southeast Asia.

Resource depletion exerts opposing pressures on co-occurring consumers to expand diets while limiting overlap with competitors. Using foraging theory as a framework, we tested the effects of prey availability on diet specialization and overlap among competing Asian predators: dhole, leopard, and tiger. We used scat analysis from a prey-poor site, combined with a quantitative synthesis of 40 other diet studies, to determine biomass of different prey types consumed by each predator.