Publications by authors named "Stegajev V"
Background: Recent reports have indicated that nonimmune cells can produce low concentrations of histamine. This observation, together with the discovery of the high-affinity histamine H receptor (H R), has added additional layers of complexity to our understanding of histamine signalling. Human oral keratinocytes (HOKs) possess a uniform H R pattern, which is deranged in oral lichen planus (OLP).
View Article and Find Full Text PDFHistamine is a neurotransmitter and chemical mediator in multiple physiological processes. Histamine H3 receptor is expressed in the nervous system, heart, and gastrointestinal tract; however, little is known about H3 receptor in skeletal muscle. The aim of this study was to investigate the role of H3 receptor in skeletal myotubes.
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- Apoptosis plays a crucial role in the development of Sjögren's syndrome (SS), an autoimmune condition that damages salivary glands.
- Research indicates that low histamine H4 receptor (H₄R) levels and impaired histamine transport in salivary cells may influence apoptosis.
- The study found that stimulation of H₄R by histamine agonist HST-10 led to reduced apoptosis in salivary gland cells, revealing a potential link between H₄R activation and immune response in SS.
Article Synopsis
- Oral lichen planus (OLP) is an autoimmune disease linked to reduced levels of high-affinity histamine H4 receptors (H4 Rs) due to high histamine levels and proinflammatory T-cell cytokines.
- Research methods included immunohistochemistry, fluorescence staining, and quantitative real-time PCR on tissue samples and cultured keratinocytes.
- Findings showed weak H4 R presence in OLP tissues, associated with mast cell hyperactivity and a negative correlation between H4 R levels and mast cell counts; this suggests a role for H4 R in maintaining healthy oral tissues, which is disrupted in OLP.
Sjögren's syndome and extragonadal sex steroid formation: a clue to a better disease control?
J Steroid Biochem Mol Biol
January 2015
Sjögren's syndrome (SS) is an autoimmune disease characterized by lymphoplasmacytoid focal adenitis leading to mucosal dryness, with 9:1 female dominance and peak incidence at menopause. Due to autoimmune adenitis it can be speculated that the normal epithelial cell renewal has failed, possibly as a result of local intracrine failure to process dehydroepiandrosterone (DHEA) to dihydrotestosterone (DHT). Local intracrine/-cellular DHT deficiency seems to predispose to SS if estrogens are low, in menopausal women and in men.
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