Screening of Nutraceuticals and Plant Extracts for Inhibition of Amyloid-β Fibrillation.

Fluorescence spectroscopy for in vitro amyloid-β (Aβ) fibrillation diagnosis and spectral fluorescence signature for the identification of bioactive compounds were applied to study traditional Ayurvedic nutraceuticals - Brahmi, Ashwagandha, Shanka pushpi, and Gotu kola - as well as their plant extracts for possible treatment of Alzheimer's disease. All samples manifest as inhibitors on three different variants of the Aβ peptide: methionine Aβ1-40, Aβ1-40, and Aβ1-42. The main compounds within the nutraceuticals were identified.

Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition.

Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer's disease patients. Related drugs preventing this peptide fibril accumulation bear the potential of considerable medical and social value. In this study, we performed fibrillation inhibition tests with eight different medical plant extracts and nutraceuticals using fluorescence spectroscopy.