Synopsis of recent research by authors named "Steffen Heckl"
Steffen Heckl's recent research primarily focuses on the interplay between immune checkpoints like PD-L1 and tumor microenvironments, particularly in pancreatic ductal adenocarcinoma (PDAC) and gastric cancer, emphasizing their roles in immune evasion and disease progression.
His findings reveal that myofibroblasts can exert immunosuppressive effects independent of PD-L1 in PDAC liver metastasis, indicating alternative pathways of immune modulation within the tumor environment.
Additionally, his studies on LAG3 in gastric cancer and the influence of insulin on PD-L1 expression further underscore the complexity of immune interactions and potential therapeutic targets in solid tumors.
