Publications by authors named "Steffen Brinkmann"
Article Synopsis
- Filamentous microorganisms, like fungi, have complex structures made up of branched hyphae, and accurately measuring the mechanical properties of these hyphae is essential for understanding their behavior.
- This study introduces a novel microfluidic system that measures the bending stiffness of individual fungal hyphae more accurately by positioning the samples away from interfering walls, resulting in better measurement outcomes.
- The findings indicate that the bending stiffness of certain hyphae is significantly higher than previously recorded, while the Young's Modulus, describing the cell wall elasticity, shows similar values across different fungal types, aiding future research on how cultivation conditions affect hyphal properties and overall fungus behavior.
Microbioreactors increase information output in biopharmaceutical screening applications because they can be operated in parallel without consuming large quantities of the pharmaceutical formulations being tested. A capillary wave microbioreactor (cwMBR) has recently been reported, allowing cost-efficient parallelization in an array that can be activated for mixing as a whole. Although impedance spectroscopy can directly distinguish between dead and viable cells, the monitoring of cells in suspension within bioreactors is challenging because the signal is influenced by the potentially varying properties of the culture medium.
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