Publications by authors named "Stefano Rizzieri"
Article Synopsis
- More than 500 kinases play critical roles in cellular processes, and their deregulation is linked to cancer and inflammation, with 80 clinical kinase inhibitors (CKIs) approved for use.
- CKIs often affect multiple kinases beyond their intended targets, leading to both increased effectiveness and unwanted side effects that are sometimes hard to predict.
- The study presents a novel approach using chromatin modifications to evaluate CKI effects on macrophage activation, which proved more effective than traditional methods, helping to identify CKI similarities, new specificities, and potential repurposing for inflammation control.
Protein-RNA interactions regulate gene expression and cellular functions at transcriptional and post-transcriptional levels. For this reason, identifying the binding partners of an RNA of interest remains of high importance to unveil the mechanisms behind many cellular processes. However, RNA molecules might interact transiently and dynamically with some RNA-binding proteins (RBPs), especially with non-canonical ones.
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