Is liver resection justified in advanced hepatocellular carcinoma? Results of an observational study in 464 patients.

Background And Objective: The role of liver resection in advanced hepatocellular carcinoma (multinodular or with macroscopic vascular involvement) is still controversial. The aim of this study is to evaluate the role of surgical resection compared to other therapeutic modalities in patients with advanced hepatocellular carcinoma (HCC).

Methods: Four hundred sixty four patients with HCC observed from 1991 to 2007 were included in the study.