Publications by authors named "Stefano Natangelo"
Article Synopsis
- Antibody-drug conjugates (ADCs) are designed to deliver toxic agents specifically to cancer cells, and their integration with radiation therapy (RT) has the potential for both benefits and risks.
- ADC payloads can enhance the effects of radiation, but may also cause off-target toxicities due to their interaction with normal tissues that express the same antigens.
- There is a need for more clinical research to evaluate the safety and effectiveness of combining ADCs with RT, especially considering the unknown side effects and risks associated with such treatments.
A comprehensive update of hormone-related pharmacokinetic variations associated with breast cancer drugs.
Expert Opin Drug Metab Toxicol
November 2023
Introduction: Drugs available for the treatment of breast cancer are increasing, yielding improved oncological outcomes. The efficacy and safety of anticancer drugs significantly depend on pharmacokinetic profiles, which could be influenced by several factors, such as sex hormones.
Areas Covered: This article discusses the potential hormone-related pharmacokinetic influences on novel breast cancer pharmacotherapies.