Publications by authors named "Stefano Margaritora"

Background: Esophageal perforation or postoperative leak after esophageal surgery remain a life-threatening condition. The optimal management strategy is still unclear.

Aim: To determine clinical outcomes and complications of our 15-year experience in the multidisciplinary management of esophageal perforations and anastomotic leaks.

View Article and Find Full Text PDF

: Unlike liver metastases, the role of surgery in colorectal cancer lung-limited metastases (CCLLM) is not yet established, and data are still poor. We performed a retrospective analysis to evaluate the impact of surgery on the management of CCLLM. : We retrospectively analyzed patients who received surgery for CCLLM at our Institution from January 2010 to June 2019.

View Article and Find Full Text PDF

Lung cancer is still a leading cause of cancer-related deaths worldwide. Vital to ameliorating patient survival rates are early detection, precise evaluation, and personalized treatments. Recent years have witnessed a profound transformation in the field, marked by intricate diagnostic processes and intricate therapeutic protocols that integrate diverse omics domains, heralding a paradigm shift towards personalized and preventive healthcare.

View Article and Find Full Text PDF

Dermatofibrosarcoma protuberans (DFSP) is a rare malignancy of mesenchymal origin of medium-low grade with a tendency to local recurrences but not to distant metastases. We present the case of a 37-year-old male who underwent surgical resection of a 1.2 cm DFSP lesion on the left shoulder in May 2020.

View Article and Find Full Text PDF

Background: Pneumomediastinum (PNM) is a severe complication in COVID-19 patients, potentially exacerbating morbidity and requiring heightened clinical attention. This study aims to identify risk factors, clinical characteristics, and outcomes associated with PNM in COVID-19 patients hospitalized for respiratory failure in our institution.

Methods: Among 4513 patients admitted in our institution and testing positive for COVID-19 infection during the peak of the COVID-19 pandemic in Italy (1 March 2020 to 31 July 2020), we conducted a single-center, retrospective case-control study focusing our analysis on those with severe disease (respiratory failure).

View Article and Find Full Text PDF
Article Synopsis
  • The ongoing FPG500 program aims to provide personalized targeted therapies for non-small cell lung cancer (NSCLC) based on genetic profiling, assessing patient eligibility through comprehensive genome profiling (CGP).
  • In 2022, a significant study involving 283 NSCLC patients revealed that 93% were eligible for sequencing, with 76% undergoing high-throughput genomic analysis, leading to the identification of potential driver mutations in 59% of them.
  • Results showed varying progression-free survival (PFS) and overall survival (OS) rates dependent on the type of treatment received, emphasizing the benefits of implementing CGP and molecular tumor board evaluations in improving patient outcomes.
View Article and Find Full Text PDF

Our case presents a unique occurrence marking the first documentation of a connection between a typical carcinoid in the context of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and vascular anomalies, including a right-sided aortic arch with Kommerell's diverticulum. Kommerell's diverticulum is a rare congenital anomaly. The lusoria subclavian artery, another developmental anomaly, arises from the right aortic arch instead of the typical left side.

View Article and Find Full Text PDF

: Intraoperative fluid management based on pulse pressure variation has shown potential to reduce postoperative pulmonary complications (PPCs) and improve clinical outcomes in various surgical settings. However, its efficacy and safety have not been assessed in patients undergoing thoracic surgery with one-lung ventilation. : Patients scheduled for pulmonary lobectomy using uniportal video-assisted thoracic surgery approach were randomly assigned to two groups.

View Article and Find Full Text PDF
Article Synopsis
  • Pulmonary metastasectomy (PM) is effective for treating oligometastatic cancer and aims to preserve lung function and quality of life through a lung-sparing surgical approach.
  • The manuscript discusses the authors' experience with a unique technique called uniportal laser-assisted VATS (U-LA-VATS) for PM, emphasizing the use of specialized laser equipment and tools during the procedure.
  • Out of 98 patients who had PM between March 2021 and November 2023, 24 were treated with the laser-assisted method, with the study presenting their results and comparing them to existing literature on the topic.
View Article and Find Full Text PDF
Article Synopsis
  • The study analyzes the genetic profiles of recurrent thymomas, using samples from 23 patients out of a cohort of 426 thymomas for comparison with primary tumors and a control group of non-recurrent cases.
  • Comprehensive genetic profiling (CGP) was conducted using the NGS Tru-Sight Oncology assay, revealing no significant differences in genetic alterations between initial tumors and recurrent ones, nor between recurrent and non-recurrent thymomas.
  • However, it was found that cell cycle control gene alterations are linked with early recurrence, and over 50% of patients may qualify for potential targeted therapies through a precision medicine approach.
View Article and Find Full Text PDF

Background: The advantages of video-assisted thoracic surgery (VATS) are well-recognized in several studies. However, in the cases of advanced lung cancer after neoadjuvant chemotherapy (nCT), the role of VATS is still questionable, with concerns about safety, technical feasibility, and oncological completeness. The aim of this study was to assess the impact of nCT on patients who had undergone uniportal VATS (U-VATS) anatomic lung resections for lung cancer, by comparing the short-term outcomes of patients after nCT with case-matched counterparts (treated by surgery alone).

View Article and Find Full Text PDF

Introduction: The 'surgically performed' continuous superficial serratus anterior plane block (continuous s-SAPB) was never described before in uniportal video-assisted thoracic surgery (uniportal VATS) surgery. The aim of the study was to evaluate the safety and efficacy of the technique.

Patients And Methods: Between March 2022 and April 2023, 50 patients, undergone uniportal VATS surgery at our thoracic surgery department, were scheduled for a surgically performed continuous s-SAPB as post-operative analgesia protocol.

View Article and Find Full Text PDF
Article Synopsis
  • A study analyzed the neurological outcomes of patients over 65 with myasthenia gravis (MG) who underwent thymectomy for thymoma between 2000 and 2022, focusing on a cohort of 66 patients affected by both conditions.
  • Most patients showed significant improvement post-surgery, with 88% reporting better neurological status, although the study found no clear link between outcomes and various factors such as age of MG onset or type of surgery.
  • The results suggest thymectomy is effective for improving symptoms in older MG patients, and further clinical trials are recommended to investigate the benefits of minimally invasive surgery in this group.
View Article and Find Full Text PDF

Thymic cysts are rare, radiological diagnosis is often incidental, and cysts seldom assume clinical relevance for symptoms of compression. Thymoma were occasionally found inside both complex and simple thymic cysts. Given the challenges in accurately clinical diagnosing and since the occasionally discovering of thymoma inside both complex and simple thymic cysts, the management of thymic cysts remains controversial.

View Article and Find Full Text PDF

Artificial Intelligence (AI) has revolutionized the management of non-small-cell lung cancer (NSCLC) by enhancing different aspects, including staging, prognosis assessment, treatment prediction, response evaluation, recurrence/prognosis prediction, and personalized prognostic assessment. AI algorithms may accurately classify NSCLC stages using machine learning techniques and deep imaging data analysis. This could potentially improve precision and efficiency in staging, facilitating personalized treatment decisions.

View Article and Find Full Text PDF
Article Synopsis
  • A large multicenter study across 15 Italian hospitals evaluated the early and long-term outcomes of robot-assisted thoracoscopic thymectomy for thymic epithelial tumors, enrolling 669 patients from 2002 to 2022.
  • The study found that most patients (98%) underwent complete thymectomy with a low incidence of open conversion (3.4%) and no perioperative mortality; however, 7.7% experienced postoperative complications.
  • Results showed effective oncological outcomes with only 2 patients dying from tumor-related causes during follow-up, and the 5- and 10-year recurrence rates were low at 7.4% and 8.3%, respectively, indicating the procedure's safety and effectiveness.
View Article and Find Full Text PDF

Background: Completion lobectomy (CL) following a prior resection in the same lobe may be complicated by severe pleural or hilar adhesions. The role of uniportal video-assisted thoracoscopic surgery (U-VATS) has never been evaluated in this setting.

Methods: Data were collected from two Italian centers.

View Article and Find Full Text PDF