Characterization of solid dispersions of itraconazole and vitamin E TPGS prepared by microwave technology.

Background: This study describes the influence of microwave irradiation (MW) on the preparation and properties of solvent-free solid dispersions (SDs) employing vitamin E D-α-tocopheryl polyethylene glycol (TPGS) 1000 succinate, with itraconazole as a model drug.

Materials And Methods: Itraconazole is characterized by low aqueous solubility and vitamin E TPGS was chosen as the surfactant carrier for the formulation of MW solid dispersions in different ratios. Their physicochemical characteristics were investigated by means of powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy and hot-stage microscopy.