Publications by authors named "Stefano Kanitz"
Article Synopsis
- Bisphenol A (BPA) is a significant endocrine disruptor that leads to DNA adduct formation in the liver and mammary tissues when administered orally to mice.
- The study investigated the effects of two chemopreventive agents, budesonide (BUD) and phenethyl isothiocyanate (PEITC), on BPA-induced DNA damage and protein changes in mice over 8 days.
- While PEITC reduced BPA-induced DNA adducts at a high dose and both agents altered protein profiles, neither BUD nor PEITC completely reverted the changes caused by BPA exposure, highlighting the complexity of their protective effects.
Endocrine disruptors (EDs) represent a major toxicological and public health issue, and the xenoestrogen bisphenol A (BPA) has received much attention due to its high production volume and widespread human exposure. Also, due to its similarity to diethylstilbestrol, a known human carcinogen, BPA has been investigated for its genotoxic and carcinogenic properties, but the results have been either inconclusive or controversial. Metabolically activated BPA has previously been shown to form DNA adducts both in vitro and in rat liver.
View Article and Find Full Text PDFExposure to active and passive smoking during pregnancy and severe small for gestational age at term.
J Matern Fetal Neonatal Med
September 2008
Objective: The objective of this study was to assess the relationship between active smoking as well as environmental tobacco smoke (ETS) exposure and severe small for gestational age (SGA) at term in a sample of pregnant Italian women.
Methods: A case-control study was conducted in nine cities in Italy between October 1999 and September 2000. Cases of severe SGA were singleton, live born, at term children with a birth weight
The aim of this study was to assess the relationship between preterm/early preterm delivery and active smoking as well as environmental tobacco smoke (ETS) exposure in a sample of pregnant Italian women. A case-control study was conducted in nine cities in Italy between October 1999 and September 2000. Cases of preterm birth were singleton babies born before the 37th gestational week; babies born before the 35th gestational week were considered early preterm births.
View Article and Find Full Text PDFChlorination by-products (CBPs) in drinking water have been associated with an increased risk of adverse pregnancy outcomes, including small for gestational age at term (term-SGA) and preterm delivery. Epidemiological evidence is weakened by a generally inaccurate exposure assessment, often at an ecological level. A case control study with incident cases was performed in nine Italian towns between October 1999 and September 2000.
View Article and Find Full Text PDF