The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14-18-Year-Old Slovak Adolescents.

The prevalence of cardiometabolic risk factors has increased in Slovakian adolescents as a result of serious lifestyle changes. This cross-sectional study aimed to assess the prevalence of insulin resistance (IR) and the associations with cardiometabolic and selected lifestyle risk factors in a sample of Slovak adolescents. In total, 2629 adolescents (45.

Risk behavioral survey in the sample of Slovak adolescents.

Objective: The study was aimed to assess risky behavioral factors in the sample of Slovak adolescents.

Background: Health-risk behavior contributes to the leading causes of morbidity and mortality among youth and adults.

Materials And Methods: The Youth and Parents Risk Factor Behavior Survey (YABS), based on bilateral US-Slovak project, is an ongoing cross-sectional school-based survey initiated in Bratislava as a model region.

Lenalidomide and dexamethasone in treatment of patients with relapsed and refractory multiple myeloma - analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies.

Lenalidomide (LEN) is an immunomodulator with clinical activity against myeloma cells. Based on the pivotal phase 3 trials MM-009 and MM010, the combination of lenalidomide and dexamethasone(DEX) was approved for patients with multiple myeloma who received at least one prior therapy. Here, we evaluated LEN/DEX therapy in unselected population and subsequently in selected sub-groups of patients with relapsed/refractory multiple myeloma followed in the Registry of Monoclonal Gammopathies of the Czech Myeloma Group.

Exposure to Environmental Tobacco Smoke in Relation to Behavioral, Emotional, Social and Health Indicators of Slovak School Children.

Environmental tobacco smoke (ETS) exposure has been shown in general as a major environmental risk factor and deserves attention in vulnerable population groups. The aim of the project is to analyze the relationships among the ETS and behavior and health in 6−15-year-old children in Slovakia. The status of physical and mental health of children in relation to exposure to tobacco smoke was examined in a representative group of 1478 school children.

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma.

Background: The genome of multiple myeloma (MM) cells is extremely unstable, characterized by a complex combination of structure and numerical abnormalities. It seems that there are several "myeloma subgroups" which differ in expression profile, clinical manifestations, prognoses and treatment response. In our previous work, the list of 35 candidate genes with a known role in carcinogenesis and associated with centrosome structure/function was used as a display of molecular heterogeneity with an impact in myeloma pathogenesis.

Laparoscopic splenectomy in pregnancy - from contraindication to golden standard.

Laparoscopy has been holding its strong position within visceral surgery for decades. For several diagnoses, laparoscopy became the method of first choice. Laparoscopic splenectomy is a standardized procedure in patients indicated mostly due to haematological disorders.

Cell cycle genes co-expression in multiple myeloma and plasma cell leukemia.

The objective of this study was to describe co-expression correlations of cell cycle regulatory genes in multiple myeloma (MM) and plasma cell leukemia (PCL). Our results highlight the presence of dynamic equilibrium between co-expression of activator and inhibitor gene sets. Moreover inhibitor set is more sensitive to the activator changes, not vice versa.

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma.

Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation of cell cycle, mitosis, DNA repair and proliferation.

Community response to environmental noise and the impact on cardiovascular risk score.

Objective: The objective of our study was to investigate and evaluate the relationship between road traffic noise and cardiovascular risk.

Methods: The study sample (n=659; 36.9% male, 63.

[Immunohistochemical detection of ZAP-70 protein and its importance in the diagnostics of B-CLL].

Chronic B-lymphocytic leukemia (B-CLL) is one of the most frequent diseases of the lymphatic system in adults. It is known for its variable course--from benign to prospectless forms. Reliable prognostic markers are needed to precify the diagnosis and the correct therapy.

Positive and negative trends in university students' food intake.

In the time period 1992-2004 the food intake data (24 hour recall, frequency questionnaire) in 3 417 students of Medical Faculty Comenius University in Bratislava (1257 men and 2160 women, the mean age 22.38 +/- 1.34) were obtained.

Community noise annoyance assessment in an urban agglomeration.

In urban areas community noise is one of the important factors in producing deterioration of both well-being and the quality of life. The aim of the study was to compare two noise annoyance surveys and two noise annoyance scales in the period of 15 years in selected areas of Slovak capital Bratislava, to calculate risks of community noise annoyance and disturbance in the observed samples. Noise annoyance risks were calculated by bivariate and stratified analysis in the form of odds ratio and Mantel-Haenszel weighted odds ratio from 2x2 and 2xn tables.

Did the nutrition of Slovak medical students change? A comparison after 15 years.

Objective: Authors aimed at positive and negative changes evaluation in nutrition and nutritional status of university-medical students comparing the situation in years 1984 and 1999. They were trying to determine, how was the nutrition of current medical students influenced by food consumption changes in the Slovak population and price liberalization of the food-stuffs as well.

Material And Methods: Seven day reports from the year 1984 (199 students) and from the year 1999 (228 students) were processed using Food Research Institute, Food Composition Database and Programme.

Stress and health-related behaviour, personality characteristics and blood pressure in older school children.

Background: Frequent stress contributes to physical and psychical disorders already in school-age children. Subjective evaluation of stress level is considered adequately informative for differentiating eustress and distress.

Objectives: Assessment of the extent of stress and connections with health-related factors and characteristics is a precondition for health promotion and stress prevention in school children.